recent publications
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academic article
- McCoy, L. E., Falkowska, E., Doores, K. J., Le, K., Sok, D., van Gils, M. J., Euler, Z., Burger, J. A., Seaman, M. S., Sanders, R. W., Schuitemaker, H., Poignard, P., et al. Incomplete neutralization and deviation from sigmoidal neutralization curves for HIV broadly neutralizing monoclonal antibodies PLoS Pathogens 2015 11:e1005110 DOI:10.1371/journal.ppat.1005110 PMID:26267277 PMCID:PMC4534392
- Pritchard, L. K., Vasiljevic, S., Ozorowski, G., Seabright, G. E., Cupo, A., Ringe, R., Kim, H. J., Sanders, R. W., Doores, K. J., Burton, D. R., Wilson, I. A., Ward, A. B., et al. Structural constraints determine the glycosylation of HIV-1 envelope trimers Cell Reports 2015 11:1604-1613 DOI:10.1016/j.celrep.2015.05.017 PMID:26051934 PMCID:PMC4555872
- Pritchard, L. K., Spencer, D. I. R., Royle, L., Bonomelli, C., Seabright, G. E., Behrens, A. J., Kulp, D. W., Menis, S., Krumm, S. A., Dunlop, D. C., Crispin, D. J., Bowden, T. A., et al. Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies Nature Communications 2015 6:7479 DOI:10.1038/ncomms8479 PMID:26105115 PMCID:PMC4500839
- Doores, K. J., Kong, L., Krumm, S. A., Le, K. M., Sok, D., Laserson, U., Garces, F., Poignard, P., Wilson, I. A., Burton, D. R. Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope Journal of Virology 2015 89:1105-1118 DOI:10.1128/jvi02905-14 PMID:25378488 PMCID:PMC4300629
- Falkowska, E., Le, K. M., Ramos, A., Doores, K. J., Lee, J. H., Blattner, C., Ramirez, A., Derking, R., van Gils, M. J., Liang, C. H., McBride, R., von Bredow, B., et al. Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers Immunity 2014 40:657-668 DOI:10.1016/j.immuni.2014.04.009 PMID:24768347 PMCID:PMC4070425
- Sok, D., Doores, K. J., Briney, B., Le, K. M., Saye-Francisco, K. L., Ramos, A., Kulp, D. W., Julien, J. P., Menis, S., Wickramasinghe, L., Seaman, M. S., Schief, W. R., et al. Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV Science Translational Medicine 2014 6:236ra63 DOI:10.1126/scitranslmed.3008104 PMID:24828077 PMCID:PMC4095976
- Julien, J. P., Sok, D., Khayat, R., Lee, J. H., Doores, K. J., Walker, L. M., Ramos, A., Diwanji, D. C., Pejchal, R., Cupo, A., Katpally, U., Depetris, R. S., et al. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans PLoS Pathogens 2013 9:e1003342 DOI:10.1371/journal.ppat.1003342 PMID:23658524 PMCID:PMC3642082
- Ota, T., Doyle-Cooper, C., Cooper, A. B., Doores, K. J., Aoki-Ota, M., Le, K., Schief, W. R., Wyatt, R. T., Burton, D. R., Nemazee, D. B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates Journal of Immunology 2013 191:3179-3185 DOI:10.4049/jimmunol.1301283 PMID:23940273 PMCID:PMC3773231
- Kong, L., Lee, J. H., Doores, K. J., Murin, C. D., Julien, J. P., McBride, R., Liu, Y., Marozsan, A., Cupo, A., Klasse, P. J., Hoffenberg, S., Caulfield, M., et al. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120 Nature Structural & Molecular Biology 2013 20:796-803 DOI:10.1038/nsmb.2594 PMID:23708606 PMCID:PMC3823233
- Doores, K. J., Huber, M., Le, K. M., Wang, S. K., Doyle-Cooper, C., Cooper, A., Pantophlet, R., Wong, C. H., Nemazee, D., Burton, D. R. 2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies Journal of Virology 2013 87:2234-2241 DOI:10.1128/jvi.02820-12 PMID:23221565 PMCID:PMC3571453
- Ota, T., Doyle-Cooper, C., Cooper, A. B., Huber, M., Falkowska, E., Doores, K. J., Hangartner, L., Le, K., Sok, D., Jardine, J., Lifson, J., Wu, X. L., et al. Anti-HIV B Cell lines as candidate vaccine biosensors Journal of Immunology 2012 189:4816-4824 DOI:10.4049/jimmunol.1202165 PMID:23066156 PMCID:PMC3626558
- Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P. S., Wang, S. K., Stanfield, R. L., Julien, J. P., Ramos, A., Crispin, M., Depetris, R., Katpally, U., et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Science 2011 334:1097-1103 DOI:10.1126/science.1213256 PMID:21998254 PMCID:PMC3280215
- Walker, L. M., Huber, M., Doores, K. J., Falkowska, E., Pejchal, R., Julien, J. P., Wang, S. K., Ramos, A., Chan-Hui, P. Y., Moyle, M., Mitcham, J. L., Hammond, P. W., et al. Broad neutralization coverage of HIV by multiple highly potent antibodies Nature 2011 477:466-470 DOI:10.1038/nature10373 PMID:21849977 PMCID:PMC3393110
- Bonomelli, C., Doores, K. J., Dunlop, D. C., Thaney, V., Dwek, R. A., Burton, D. R., Crispin, M., Scanlan, C. N. The glycan shield of hiv is predominantly oligomannose independently of production system or viral clade PLoS One 2011 6:e23521 DOI:10.1371/journal.pone.0023521 PMID:21858152 PMCID:PMC3156772
- Doores, K. J., Fulton, Z., Hong, V., Patel, M. K., Scanlan, C. N., Wormald, M. R., Finn, M. G., Burton, D. R., Wilson, I. A., Davis, B. G. A nonself sugar mimic of the hiv glycan shield shows enhanced antigenicity Proceedings of the National Academy of Sciences of the United States of America 2010 107:17107-17112 DOI:10.1073/pnas.1002717107 PMID:20852065 PMCID:PMC2951454
- Doores, K. J., Fulton, Z., Huber, M., Wilson, I. A., Burton, D. R. Antibody 2g12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the hiv-1 glycan shield if domain exchanged Journal of Virology 2010 84:10690-10699 DOI:10.1128/jvi.01110-10 PMID:20702629 PMCID:PMC2950587
- Doores, K. J., Burton, D. R. Variable loop glycan dependency of the broad and potent hiv-1-neutralizing antibodies pg9 and pg16 Journal of Virology 2010 84:10510-10521 DOI:10.1128/jvi.00552-10 PMID:20686044 PMCID:PMC2950566
- Huber, M., Le, K. M., Doores, K. J., Fulton, Z., Stanfield, R. L., Wilson, I. A., Burton, D. R. Very few substitutions in a germ line antibody are required to initiate significant domain exchange Journal of Virology 2010 84:10700-10707 DOI:10.1128/jvi.01111-10 PMID:20702640 PMCID:PMC2950590
- Doores, K. J., Bonomelli, C., Harvey, D. J., Vasiljevic, S., Dwek, R. A., Burton, D. R., Crispin, M., Scanlan, C. N. Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens Proceedings of the National Academy of Sciences of the United States of America 2010 107:13800-13805 DOI:10.1073/pnas.1006498107 PMID:20643940 PMCID:PMC2922250
- Astronomo, R. D., Kaltgrad, E., Udit, A. K., Wang, S. K., Doores, K. J., Huang, C. Y., Pantophlet, R., Paulson, J. C., Wong, C. H., Finn, M. G., Burton, D. R. Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds Chemistry & Biology 2010 17:357-370 DOI:10.1016/j.chembiol.2010.03.012 PMID:20416507 PMCID:PMC2867452