recent publications

• academic article

  • McCoy, L. E., Falkowska, E., Doores, K. J., Le, K., Sok, D., van Gils, M. J., Euler, Z., Burger, J. A., Seaman, M. S., Sanders, R. W., Schuitemaker, H., Poignard, P., et al. Incomplete neutralization and deviation from sigmoidal neutralization curves for HIV broadly neutralizing monoclonal antibodies PLoS Pathogens  2015 11:e1005110  DOI:10.1371/journal.ppat.1005110  PMID:26267277  PMCID:PMC4534392
  • Pritchard, L. K., Vasiljevic, S., Ozorowski, G., Seabright, G. E., Cupo, A., Ringe, R., Kim, H. J., Sanders, R. W., Doores, K. J., Burton, D. R., Wilson, I. A., Ward, A. B., et al. Structural constraints determine the glycosylation of HIV-1 envelope trimers Cell Reports  2015 11:1604-1613  DOI:10.1016/j.celrep.2015.05.017  PMID:26051934  PMCID:PMC4555872
  • Pritchard, L. K., Spencer, D. I. R., Royle, L., Bonomelli, C., Seabright, G. E., Behrens, A. J., Kulp, D. W., Menis, S., Krumm, S. A., Dunlop, D. C., Crispin, D. J., Bowden, T. A., et al. Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies Nature Communications  2015 6:7479  DOI:10.1038/ncomms8479  PMID:26105115  PMCID:PMC4500839
  • Doores, K. J., Kong, L., Krumm, S. A., Le, K. M., Sok, D., Laserson, U., Garces, F., Poignard, P., Wilson, I. A., Burton, D. R. Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope Journal of Virology  2015 89:1105-1118  DOI:10.1128/jvi02905-14  PMID:25378488  PMCID:PMC4300629
  • Falkowska, E., Le, K. M., Ramos, A., Doores, K. J., Lee, J. H., Blattner, C., Ramirez, A., Derking, R., van Gils, M. J., Liang, C. H., McBride, R., von Bredow, B., et al. Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers Immunity  2014 40:657-668  DOI:10.1016/j.immuni.2014.04.009  PMID:24768347  PMCID:PMC4070425
  • Sok, D., Doores, K. J., Briney, B., Le, K. M., Saye-Francisco, K. L., Ramos, A., Kulp, D. W., Julien, J. P., Menis, S., Wickramasinghe, L., Seaman, M. S., Schief, W. R., et al. Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV Science Translational Medicine  2014 6:236ra63  DOI:10.1126/scitranslmed.3008104  PMID:24828077  PMCID:PMC4095976
  • Julien, J. P., Sok, D., Khayat, R., Lee, J. H., Doores, K. J., Walker, L. M., Ramos, A., Diwanji, D. C., Pejchal, R., Cupo, A., Katpally, U., Depetris, R. S., et al. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans PLoS Pathogens  2013 9:e1003342  DOI:10.1371/journal.ppat.1003342  PMID:23658524  PMCID:PMC3642082
  • Ota, T., Doyle-Cooper, C., Cooper, A. B., Doores, K. J., Aoki-Ota, M., Le, K., Schief, W. R., Wyatt, R. T., Burton, D. R., Nemazee, D. B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates Journal of Immunology  2013 191:3179-3185  DOI:10.4049/jimmunol.1301283  PMID:23940273  PMCID:PMC3773231
  • Kong, L., Lee, J. H., Doores, K. J., Murin, C. D., Julien, J. P., McBride, R., Liu, Y., Marozsan, A., Cupo, A., Klasse, P. J., Hoffenberg, S., Caulfield, M., et al. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120 Nature Structural & Molecular Biology  2013 20:796-803  DOI:10.1038/nsmb.2594  PMID:23708606  PMCID:PMC3823233
  • Doores, K. J., Huber, M., Le, K. M., Wang, S. K., Doyle-Cooper, C., Cooper, A., Pantophlet, R., Wong, C. H., Nemazee, D., Burton, D. R. 2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies Journal of Virology  2013 87:2234-2241  DOI:10.1128/jvi.02820-12  PMID:23221565  PMCID:PMC3571453
  • Ota, T., Doyle-Cooper, C., Cooper, A. B., Huber, M., Falkowska, E., Doores, K. J., Hangartner, L., Le, K., Sok, D., Jardine, J., Lifson, J., Wu, X. L., et al. Anti-HIV B Cell lines as candidate vaccine biosensors Journal of Immunology  2012 189:4816-4824  DOI:10.4049/jimmunol.1202165  PMID:23066156  PMCID:PMC3626558
  • Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P. S., Wang, S. K., Stanfield, R. L., Julien, J. P., Ramos, A., Crispin, M., Depetris, R., Katpally, U., et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Science  2011 334:1097-1103  DOI:10.1126/science.1213256  PMID:21998254  PMCID:PMC3280215
  • Walker, L. M., Huber, M., Doores, K. J., Falkowska, E., Pejchal, R., Julien, J. P., Wang, S. K., Ramos, A., Chan-Hui, P. Y., Moyle, M., Mitcham, J. L., Hammond, P. W., et al. Broad neutralization coverage of HIV by multiple highly potent antibodies Nature  2011 477:466-470  DOI:10.1038/nature10373  PMID:21849977  PMCID:PMC3393110
  • Bonomelli, C., Doores, K. J., Dunlop, D. C., Thaney, V., Dwek, R. A., Burton, D. R., Crispin, M., Scanlan, C. N. The glycan shield of hiv is predominantly oligomannose independently of production system or viral clade PLoS One  2011 6:e23521  DOI:10.1371/journal.pone.0023521  PMID:21858152  PMCID:PMC3156772
  • Doores, K. J., Fulton, Z., Hong, V., Patel, M. K., Scanlan, C. N., Wormald, M. R., Finn, M. G., Burton, D. R., Wilson, I. A., Davis, B. G. A nonself sugar mimic of the hiv glycan shield shows enhanced antigenicity Proceedings of the National Academy of Sciences of the United States of America  2010 107:17107-17112  DOI:10.1073/pnas.1002717107  PMID:20852065  PMCID:PMC2951454
  • Doores, K. J., Fulton, Z., Huber, M., Wilson, I. A., Burton, D. R. Antibody 2g12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the hiv-1 glycan shield if domain exchanged Journal of Virology  2010 84:10690-10699  DOI:10.1128/jvi.01110-10  PMID:20702629  PMCID:PMC2950587
  • Doores, K. J., Burton, D. R. Variable loop glycan dependency of the broad and potent hiv-1-neutralizing antibodies pg9 and pg16 Journal of Virology  2010 84:10510-10521  DOI:10.1128/jvi.00552-10  PMID:20686044  PMCID:PMC2950566
  • Huber, M., Le, K. M., Doores, K. J., Fulton, Z., Stanfield, R. L., Wilson, I. A., Burton, D. R. Very few substitutions in a germ line antibody are required to initiate significant domain exchange Journal of Virology  2010 84:10700-10707  DOI:10.1128/jvi.01111-10  PMID:20702640  PMCID:PMC2950590
  • Doores, K. J., Bonomelli, C., Harvey, D. J., Vasiljevic, S., Dwek, R. A., Burton, D. R., Crispin, M., Scanlan, C. N. Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens Proceedings of the National Academy of Sciences of the United States of America  2010 107:13800-13805  DOI:10.1073/pnas.1006498107  PMID:20643940  PMCID:PMC2922250
  • Astronomo, R. D., Kaltgrad, E., Udit, A. K., Wang, S. K., Doores, K. J., Huang, C. Y., Pantophlet, R., Paulson, J. C., Wong, C. H., Finn, M. G., Burton, D. R. Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds Chemistry & Biology  2010 17:357-370  DOI:10.1016/j.chembiol.2010.03.012  PMID:20416507  PMCID:PMC2867452