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Protection of mice against lethal coxsackievirus b3 infection by using DNA immunization

Academic Article
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Overview

authors

  • Henke, A.
  • Wagner, E.
  • Whitton, J. Lindsay
  • Zell, R.
  • Stelzner, A.

publication date

  • October 1998

journal

  • Journal of Virology  Journal

abstract

  • Vaccination with DNA and recombinant vaccinia viruses (rec.VV) has been studied with the coxsackievirus B3 (CVB3) model system. Plasmids encoding all structural proteins of CVB3, when injected intramuscularly, induced only low levels of virus-specific antibodies. However, DNA vaccination with the major structural protein VP1 protected 72.2% of mice from lethal challenge, whereas VP1 expressed by rec.VV was much less efficient.

subject areas

  • Animals
  • Antibodies, Viral
  • Coxsackievirus Infections
  • Enterovirus B, Human
  • Enzyme-Linked Immunosorbent Assay
  • Mice
  • Mice, Inbred BALB C
  • Plasmids
  • Vaccines, DNA
  • Vaccinia virus
  • Viral Structural Proteins
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Identity

PubMed Central ID

  • PMC110201

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 9733878
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Additional Document Info

start page

  • 8327

end page

  • 8331

volume

  • 72

issue

  • 10

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