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Anxiolytic-like effects of sinapic acid in mice

Academic Article
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Overview

authors

  • Yoon, B. H.
  • Jung, J. W.
  • Lee, Jiing-Dwan
  • Cho, Y. W.
  • Jang, Choon-Gon
  • Jin, C.
  • Oh, T. H.
  • Ryu, J. H.

publication date

  • June 2007

journal

  • Life Sciences  Journal

abstract

  • Sinapic acid is a phenylpropanoid compound and is found in various herbal materials and high-bran cereals. With the exception of its antioxidant activities, the pharmacological properties of sinapic acid have been rarely reported. The purpose of this study was to characterize the putative anxiolytic-like properties of sinapic acid using an elevated plus-maze (EPM) and hole-board test. Control mice were orally treated with an equal volume of vehicle (10% Tween 80 solution), and positive control mice were treated with diazepam (1 mg/kg, i.p.). Sinapic acid (4 mg/kg, p.o.) significantly increased the percentages of time spent in the open arms of the EPM test (P<0.05). In the hole-board test, sinapic acid also significantly increased the number of head-dips at 4 mg/kg (P<0.05). In addition, the anxiolytic-like properties of sinapic acid examined in the EPM test were blocked by flumazenil or bicuculline, which are GABA(A) antagonists. Moreover, sinapic acid markedly potentiated GABA current in single cortical neurons in a dose-dependant manner, and reactive I(GABA) increased to 1.8 times at 1 muM of sinapic acid. These results suggested that sinapic acid is a prominent anxiolytic agent, and that its anxiolytic-like effects are mediated via GABA(A) receptors and potentiating Cl(-) currents.

subject areas

  • Animals
  • Anti-Anxiety Agents
  • Anxiety
  • Bicuculline
  • Cerebral Cortex
  • Chloride Channels
  • Coumaric Acids
  • Diazepam
  • Electrophysiology
  • Flumazenil
  • GABA Antagonists
  • GABA Modulators
  • Male
  • Mice
  • Mice, Inbred ICR
  • Motor Activity
  • Muscle Relaxation
  • Muscle, Smooth
  • Neurons
  • Neurotransmitter Agents
  • Piperazines
  • Postural Balance
  • Pyridines
  • Serotonin Antagonists
  • gamma-Aminobutyric Acid
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Research

keywords

  • GABA(A) receptor
  • anxiolytic-like effect
  • chloride current
  • elevated plus-maze test
  • hole-board test
  • sinapic acid
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Identity

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/j.lfs.2007.05.007

PubMed ID

  • 17570441
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Additional Document Info

start page

  • 234

end page

  • 240

volume

  • 81

issue

  • 3

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