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Chemical etiology of nucleic acid structure: Comparing pentopyranosyl-(2 '-> 4 ') oligonucleotides with RNA

Academic Article
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Overview

authors

  • Beier, M.
  • Reck, F.
  • Wagner, T.
  • Krishnamurthy, Ramanarayanan
  • Eschenmoser, A.

publication date

  • January 1999

journal

  • Science  Journal

abstract

  • All four members of the family of pentopyranosyl-(2'-->4') oligonucleotide systems that contain beta-ribo-, beta-xylo-, alpha-lyxo-, or alpha-arabinopyranosyl units as repeating sugar building blocks are found to be much stronger Watson-Crick base-pairing systems than RNA. The alpha-arabinopyranosyl system is the strongest of all and in fact belongs to the strongest oligonucleotide base-pairing systems known. Whatever the chemical determinants by which nature selected RNA as a genetic system, maximization of base-pairing strengths within the domain of pentose-derived oligonucleotide systems was not the critical selection criterion.

subject areas

  • Arabinose
  • Base Pairing
  • Circular Dichroism
  • Evolution, Molecular
  • Nucleic Acid Conformation
  • Nucleic Acid Denaturation
  • Oligonucleotides
  • Oligoribonucleotides
  • Pentoses
  • RNA
  • Ribose
  • Temperature
  • Thermodynamics
  • Xylose
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.283.5402.699

PubMed ID

  • 9924032
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Additional Document Info

start page

  • 699

end page

  • 703

volume

  • 283

issue

  • 5402

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