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Regulation of the oxidative stress response by the hpr gene in bacillus-subtilis

Academic Article
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Overview

authors

  • Dowds, B. C. A.
  • Hoch, James

publication date

  • 1991

journal

  • Journal of General Microbiology  Journal

abstract

  • Bacillus subtilis mutants with null mutations in the spo0 A gene are resistant to oxidative stress during the exponential phase of growth. This resistance phenotype can be suppressed by mutations in the abrB gene, or in the hpr gene. Both of these gene products are negative regulatory proteins which are over-produced in a spo0 A strain, and the over-production of the hpr gene product results from over-production of the abrB gene product. The results suggested that the resistance to oxidative stress in a spo0 A strain is due to the lack of a protein directly controlled by the hpr negative regulator. Other mutations in the spo0 A gene conferring resistance to ethanol stress (eth) or suppressors of sporulation phenotypes (sof) had no effect on the sensitivity to oxidative stress of strains bearing them.

subject areas

  • Bacillus subtilis
  • Gene Expression Regulation, Bacterial
  • Genes, Bacterial
  • Mutation
  • Oxidation-Reduction
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Identity

International Standard Serial Number (ISSN)

  • 0022-1287

PubMed ID

  • 1907636
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Additional Document Info

start page

  • 1121

end page

  • 1125

volume

  • 137

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