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Nociceptors: The sensors of the pain pathway

Academic Article
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Overview

authors

  • Dubin, Adrienne
  • Patapoutian, Ardem

publication date

  • November 2010

journal

  • Journal of Clinical Investigation  Journal

abstract

  • Specialized peripheral sensory neurons known as nociceptors alert us to potentially damaging stimuli at the skin by detecting extremes in temperature and pressure and injury-related chemicals, and transducing these stimuli into long-ranging electrical signals that are relayed to higher brain centers. The activation of functionally distinct cutaneous nociceptor populations and the processing of information they convey provide a rich diversity of pain qualities. Current work in this field is providing researchers with a more thorough understanding of nociceptor cell biology at molecular and systems levels and insight that will allow the targeted design of novel pain therapeutics.

subject areas

  • Animals
  • Hot Temperature
  • Humans
  • Ion Channels
  • Mechanotransduction, Cellular
  • Nervous System
  • Nociceptors
  • Pain
  • Pain Threshold
  • Sensation
  • Signal Transduction
  • Skin
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Identity

PubMed Central ID

  • PMC2964977

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci42843

PubMed ID

  • 21041958
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Additional Document Info

start page

  • 3760

end page

  • 3772

volume

  • 120

issue

  • 11

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