recent publications

• academic article

  • Wetterholm, A., Molina, D. M., Nordlund, P., Eshaghi, S., Haeggstrom, J. Z. High-level expression, purification, and crystallization of recombinant rat leukotriene c-4 synthase from the yeast pichia pastoris Protein Expression and Purification  2008 60:1-6  DOI:10.1016/j.pep.2008.03.005  PMID:18440824
  • Molina, D. M., Cornvik, T., Eshaghi, S., Haeggstrom, J. Z., Nordlund, P., Sabet, M. I. Engineering membrane protein overproduction in escherichia coli Protein Science  2008 17:673-680  DOI:10.1110/ps.073242508  PMID:18305199  PMCID:PMC2271156
  • Qiu, H., Gabrielsen, A., Agardh, H. E., Wan, M., Wetterholm, A., Wong, C. H., Hedin, U., Swedenborg, J., Hansson, G. K., Samuelsson, B., Paulsson-Berne, G., Haeggstrom, J. Z. Expression of 5-lipoxygenase and leukotriene a(4) hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability Proceedings of the National Academy of Sciences of the United States of America  2006 103:8161-8166  DOI:10.1073/pnas.0602414103  PMID:16698924  PMCID:PMC1459628
  • Thunnissen, Mmgm, Andersson, B., Samuelsson, B., Wong, C. H., Haeggstrom, J. Z. Crystal structures of leukotriene a(4) hydrolase in complex with captopril and two competitive tight-binding inhibitors FASEB Journal  2002 16:1648-1650  DOI:10.1096/fj.01-1017fje  PMID:12207002
  • Wetterholm, A., Haeggstrom, J. Z., Samuelsson, B., Yuan, W., Munoz, B., Wong, C. H. Potent and selective inhibitors of leukotriene a(4) hydrolase - effects on purified enzyme and human polymorphonuclear leukocytes Journal of Pharmacology and Experimental Therapeutics  1995 275:31-37  PMID:7562564
  • Hogg, J. H., Ollmann, I. R., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B., Wong, C. H. Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase Bioorganic & Medicinal Chemistry  1995 3:1405-1415  DOI:10.1016/0968-0896(95)00128-4  PMID:8564408
  • Ollmann, I. R., Hogg, J. H., Munoz, B., Haeggstrom, J. Z., Samuelsson, B., Wong, C. H. Investigation of the inhibition of leukotriene A4 hydrolase Bioorganic & Medicinal Chemistry  1995 3:969-995  DOI:10.1016/0968-0896(95)00078-u  PMID:7582974
  • Wei, Y. A., Munoz, B., Wong, C. H., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B. Development of selective tight-binding inhibitors of leukotriene-a4 hydrolase Journal of Medicinal Chemistry  1993 36:211-220  PMID:8423594
  • Yuan, W., Wong, C. H., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B. Novel tight-binding inhibitors of leukotriene-a(4) hydrolase Journal of the American Chemical Society  1992 114:6552-6553  DOI:10.1021/ja00042a041