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Chemistry and biology of natural and designed enediynes

Academic Article
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Overview

related to degree

  • Yue, Eddy W, Ph.D. in Organic Chemistry, Scripps Research 1991 - 1996

authors

  • Nicolaou, K.C.
  • Smith, A. L.
  • Yue, Eddy W

publication date

  • July 1993

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Ever since the initial reports of the enediyne anticancer antibiotics in the late 1980s, researchers from a number of disciplines have been devoting increasing attention to their chemistry, biology, and potential medical applications. Synthetic chemists and molecular designers have been engaged in attempts to synthesize these molecules and to model their unique architecture. Considerable efforts have been directed at understanding and mimicking the various processes involved in the targeting, activation, and DNA cleavage associated with these natural products. This review summarizes the main contributions to the field, with particular emphasis on work from our laboratories. Highlights include studies of the Bergman reaction, which is central to the mechanism of action of enediynes, the design and chemical synthesis of a number of these systems, and biological studies with selected molecules. Finally, the total synthesis of calicheamicin gamma 1I, the most prominent member of this class of naturally occurring compounds, is discussed.

subject areas

  • Aminoglycosides
  • Animals
  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Cell Line
  • Drug Delivery Systems
  • Drug Design
  • Enediynes
  • Humans
  • Models, Molecular
  • Tumor Cells, Cultured
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Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.90.13.5881

PubMed ID

  • 8327459
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Additional Document Info

start page

  • 5881

end page

  • 5888

volume

  • 90

issue

  • 13

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