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Interplay between superantigens and the immune-system

Academic Article
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Overview

authors

  • Irwin, M. J.
  • Gascoigne, Nicholas

publication date

  • November 1993

journal

  • Journal of Leukocyte Biology  Journal

abstract

  • Superantigens interact with the immune system by binding to major histocompatibility complex (MHC) class II proteins and activating T cells through the variable region of the T cell receptor beta-chain. Through this means they can cause massive proliferation and then death of a large proportion of T cells. Superantigens are produced by bacteria, mycoplasmas, retroviruses, and probably by other organisms. In some cases, the superantigen is crucial to the organism's life cycle. Mouse mammary tumor virus disseminates by activating T cells which stimulate the proliferation of B cells harboring the virus. In other cases, the superantigen may be responsible for the pathogenesis of the infection, such as in the case of Toxic Shock Syndrome. In this article, we review information on the diseases in which superantigens are involved, and the mechanisms by which the superantigens interact with T cell receptor and class II molecules.

subject areas

  • Animals
  • Histocompatibility Antigens Class II
  • Humans
  • Immune System
  • Protein Binding
  • Receptors, Antigen, T-Cell
  • Superantigens
  • T-Lymphocytes
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Research

keywords

  • ENTEROTOXIN
  • IMMUNOLOGICAL TOLERANCE
  • MLS
  • MOUSE MAMMARY TUMOR VIRUS
  • T-CELL ACTIVATION
  • T-CELL RECEPTOR
  • VARIABLE REGION
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Identity

International Standard Serial Number (ISSN)

  • 0741-5400

PubMed ID

  • 8228628
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Additional Document Info

start page

  • 495

end page

  • 503

volume

  • 54

issue

  • 5

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