Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Transgenic overexpression of interleukin-1 receptor antagonist in the CNS influences behaviour, serum corticosterone and brain monoamines

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Oprica, M.
  • Zhu, S. W.
  • Goiny, M.
  • Pham, T. M.
  • Mohammed, A. H.
  • Winblad, B.
  • Bartfai, Tamas
  • Schultzberg, M.

publication date

  • May 2005

journal

  • Brain Behavior and Immunity  Journal

abstract

  • The effects of brain-directed overexpression of human soluble interleukin-1 receptor antagonist (hsIL-1ra) on behaviour, serum corticosterone (CST) levels and concentrations of dopamine (DA), 5-hydroxytryptamine (5-HT) and their metabolites in different brain regions, were investigated in six months old homozygotic transgenic male mice (Tg hsIL-1ra(+/+)). The transgenic and age-matched wild type (WT) mice were subjected to a battery of behavioural tests for analysis of open field (OF) behaviours, anxiety in elevated plus maze (EPM), and motor performance in rotarod. One week after the last behavioural test, half of the mice from each genotype were subjected to a mild stress, while the remaining mice served as controls for the determination of serum CST levels and monoamine concentrations in different brain regions. Tg hsIL-1ra(+/+) mice had higher locomotor scores and showed less habituation in the OF test, spent more time in the open arms of the EPM and had similar motor performance as compared to WT mice. The serum CST levels were comparable, both in basal conditions and upon stress, in the two genotypes. Tg hsIL-1ra(+/+) mice had lower concentrations of DA, 5-HT and their metabolites in several brain regions, with different effects on monoamine turnover upon stress. In conclusion, brain-directed overexpression of hsIL-1ra resulted in increased locomotion and decreased habituation, an anxiolytic effect, but did not influence motor performance. Finally, the activation of hypothalamo-pituitary-adrenal (HPA)-axis was comparable in the two genotypes, however Tg hsIL-1ra(+/+) mice had a modified metabolism of brain monoamines as compared to WT mice.

subject areas

  • Animals
  • Anxiety
  • Behavior, Animal
  • Brain
  • Corticosterone
  • Dopamine
  • Exploratory Behavior
  • Humans
  • Interleukin 1 Receptor Antagonist Protein
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Mice, Transgenic
  • Psychomotor Performance
  • Receptors, Interleukin-1
  • Rotarod Performance Test
  • Serotonin
  • Sialoglycoproteins
  • Statistics, Nonparametric
  • Stress, Physiological
scroll to property group menus

Research

keywords

  • anti-inflammatory
  • anxiety
  • cytokines
  • dopamine
  • motor activity
  • mouse
  • serotonin
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0889-1591

Digital Object Identifier (DOI)

  • 10.1016/j.bbi.2004.07.006

PubMed ID

  • 15797311
scroll to property group menus

Additional Document Info

start page

  • 223

end page

  • 234

volume

  • 19

issue

  • 3

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support