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Human blood cells ultrastructural changes and mediator release after exposure to roentgenographic contrast media

Academic Article
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Overview

authors

  • Fritzler, M. J.
  • Ring, J.
  • Arroyave, C. M.
  • Tan, Eng

publication date

  • 1978

journal

  • Canadian Medical Association Journal  Journal

abstract

  • Adverse reactions to roentgenographic contrast media (RCM) are associated with the release of mediators including complement components (anaphylatoxins), histamine and serotonin. In an in vitro study of platelets and leukocytes from 20 healthy individuals, RCM-induced release of granules from basophils and platelets was correlated with the release of histamine and serotonin respectively. The release of histamine from basophils was augmented in the presence of exogenous complement; in contrast, the release of serotonin from platelets was not dependent on the addition of exogenous complement. Although individual differences were noted, iothalamate most effectively released serotonin, whereas diatrizoate most effectively released histamine.

subject areas

  • Adult
  • Basophils
  • Blood Platelets
  • Contrast Media
  • Female
  • Histamine
  • Humans
  • In Vitro Techniques
  • Leukocytes
  • Male
  • Serotonin
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Identity

PubMed Central ID

  • PMC1819105

International Standard Serial Number (ISSN)

  • 0820-3946

PubMed ID

  • 737641
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Additional Document Info

start page

  • 901

end page

  • 906

volume

  • 119

issue

  • 8

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