recent publications

• academic article

  • Ma, M., Rateb, M. E., Teng, Q., Yang, D., Rudolf, J. D., Zhu, X., Huang, Y., Zhao, L. X., Jiang, Y., Li, X., Rader, C., Duan, Y., et al. Angucyclines and angucyclinones from streptomyces sp. CB01913 featuring C-ring cleavage and expansion Journal of Natural Products  2015 78:2471-2480  DOI:10.1021/acs.jnatprod.5b00601  PMID:26335269  PMCID:PMC4845661
  • Kang, Y., Zhou, X. E., Gao, X., He, Y., Liu, W., Ishchenko, A., Barty, A., Sathish, D., Yefanov, O., Han, G. W., Xu, Q., de Waal, P. W., et al. Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser Nature  2015 523:561-567  DOI:10.1038/nature14656  PMID:26200343  PMCID:PMC4521999
  • Mei, D., Yin, Y., Wu, F., Cui, J., Zhou, H., Sun, G., Jiang, Y., Feng, Y. Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor's potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations Bioorganic & Medicinal Chemistry  2015 23:2505-2517  DOI:10.1016/j.bmc.2015.03.047  PMID:25882521
  • Hindra, Huang, T., Yang, D., Rudolf, J. D., Xie, P., Xie, G., Teng, Q., Lohman, J. R., Zhu, X., Huang, Y., Zhao, L. X., Jiang, Y., et al. Strain prioritization for natural product discovery by a high-throughput real-time PCR method Journal of Natural Products  2014 77:2296-2303  DOI:10.1021/np5006168  PMID:25238028  PMCID:PMC4208669
  • Xie, P., Ma, M., Rateb, M. E., Shaaban, K. A., Yu, Z., Huang, S. X., Zhao, L. X., Zhu, X., Yan, Y., Peterson, R. M., Lohman, J. R., Yang, D., et al. Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes Journal of Natural Products  2014 77:377-387  DOI:10.1021/np401063s  PMID:24484381  PMCID:PMC3963700
  • Wang, C., Jiang, Y., Ma, J., Wu, H., Wacker, D., Katritch, V., Han, G. W., Liu, W., Huang, X. P., Vardy, E., McCorvy, J. D., Gao, X., et al. Structural basis for molecular recognition at serotonin receptors Science  2013 340:610-614  DOI:10.1126/science.1232807  PMID:23519210  PMCID:PMC3644373
  • Wacker, D., Wang, C., Katritch, V., Han, G. W., Huang, X. P., Vardy, E., McCorvy, J. D., Jiang, Y., Chu, M., Siu, F. Y., Liu, W., Xu, H. E., et al. Structural features for functional selectivity at serotonin receptors Science  2013 340:615-619  DOI:10.1126/science.1232808  PMID:23519215  PMCID:PMC3644390
  • Tebbets, B., Yu, Z. G., Stewart, D., Zhao, L. X., Jiang, Y., Xu, L. H., Andes, D., Shen, B., Klein, B. Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: Insights into macrotetrolide drug spectrum, potency and mode of action Medical Mycology  2013 51:280-289  DOI:10.3109/13693786.2012.710917  PMID:22928922  PMCID:PMC3594352
  • Li, Y., Karagoz, G. E., Seo, Y. H., Zhang, T., Jiang, Y., Yu, Y., Duarte, A. M. S., Schwartz, S. J., Boelens, R., Carroll, K., Rudiger, S. G. D., Sun, D. Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90 Journal of Nutritional Biochemistry  2012 23:1617-1626  DOI:10.1016/j.jnutbio.2011.11.004  PMID:22444872  PMCID:PMC3386376
  • Huang, S. X., Yu, Z. G., Robert, F., Zhao, L. X., Jiang, Y., Duan, Y. W., Pelletier, J., Shen, B. Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes streptomyces sps. Yim56132 and yim56141 Journal of Antibiotics  2011 64:163-166  DOI:10.1038/ja.2010.150  PMID:21139626
  • Page, L. J., Suk, J. Y., Bazhenova, L., Fleming, S. M., Wood, M., Jiang, Y., Guo, L. T., Mizisin, A. P., Kisilevsky, R., Shelton, G. D., Balch, W. E., Kelly, J. W. Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins Proceedings of the National Academy of Sciences of the United States of America  2009 106:11125-11130  DOI:10.1073/pnas.0811753106  PMID:19549824  PMCID:PMC2708763
  • Baudhuin, L. M., Jiang, Y., Zaslavsky, A., Ishii, I., Chun, J., Xu, Y. S1p(3)-mediated akt activation and crosstalk with platelet-derived growth factor receptor (PDGFR) FASEB Journal  2003 17:341-343  DOI:10.1096/fj.03-0302fje  PMID:12631574
  • Sacher, M., Jiang, Y., Barrowman, J., Scarpa, A., Burston, J., Zhang, L., Schieltz, D., Yates, J. R., Abeliovich, H., Ferro-Novick, S. TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion EMBO Journal  1998 17:2494-2503  DOI:10.1093/emboj/17.9.2494  PMID:9564032  PMCID:PMC1170591
  • Jiang, Y., Gram, H., Zhao, M., New, L. G., Gu, J., Feng, L. L., DiPadova, F., Ulevitch, R. J., Han, J. H. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38 delta Journal of Biological Chemistry  1997 272:30122-30128  DOI:10.1074/jbc.272.48.30122  PMID:9374491
  • Huang, S., Jiang, Y., Li, Z. J., Nishida, E., Mathias, P., Lin, S. C., Ulevitch, R. J., Nemerow, G. R., Han, J. H. Apoptosis signaling pathway in t cells is composed of ice/ced-3 family proteases and map kinase kinase 6b Immunity  1997 6:739-749  DOI:10.1016/s1074-7613(00)80449-5  PMID:9208846
  • Han, J., Jiang, Y., Li, Z., Kravchenko, V. V., Ulevitch, R. J. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation Nature  1997 386:296-299  DOI:10.1038/386296a0  PMID:9069290
  • Han, J. H., Wang, X. H., Jiang, Y., Ulevitch, R. J., Lin, S. C. Identification and characterization of a predominant isoform of human mkk3 FEBS Letters  1997 403:19-22  DOI:10.1016/s0014-5793(97)00021-5  PMID:9038352
  • Jiang, Y., Li, Z. J., Schwarz, E. M., Lin, A. N., Guan, K. L., Ulevitch, R. J., Han, J. H. Structure-function studies of p38 mitogen-activated protein kinase - loop 12 influences substrate specificity and autophosphorylation, but not upstream kinase selection Journal of Biological Chemistry  1997 272:11096-11102  PMID:9111004
  • Li, Z. J., Jiang, Y., Ulevitch, R. J., Han, J. H. The primary structure of p38 gamma: A new member of p38 group of map kinases Biochemical and Biophysical Research Communications  1996 228:334-340  DOI:10.1006/bbrc.1996.1662  PMID:8920915
  • Han, J. H., Lee, J. D., Jiang, Y., Li, Z. G., Feng, L. L., Ulevitch, R. J. Characterization of the structure and function of a novel map kinase kinase (mkk6) Journal of Biological Chemistry  1996 271:2886-2891  PMID:8621675