recent publications

• academic article

  • Takuwa, N., Ohkura, S. I., Takashima, S. I., Ohtani, K., Okamoto, Y., Tanaka, T., Hirano, K., Usui, S., Wang, F., Du, W., Yoshioka, K., Banno, Y., et al. S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species Cardiovascular Research  2010 85:484-493  DOI:10.1093/cvr/cvp312  PMID:19755413  PMCID:PMC2802201
  • Romero, F. A., Du, W., Hwang, I., Rayl, T. J., Kimball, F. S., Leung, D., Hoover, H. S., Apodaca, R. L., Breitenbucher, J. G., Cravatt, B. F., Boger, D. L. Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase Journal of Medicinal Chemistry  2007 50:1058-1068  DOI:10.1021/jm0611509  PMID:17279740  PMCID:PMC2531193
  • Boger, D. L., Miyauchi, H., Du, W., Hardouin, C., Fecik, R. A., Cheng, H., Hwang, I., Hedrick, M. P., Leung, D., Acevedo, O., Guimaraes, C. R. W., Jorgensen, W. L., et al. Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics Journal of Medicinal Chemistry  2005 48:1849-1856  DOI:10.1021/jm049614v  PMID:15771430  PMCID:PMC2492884
  • Leung, D., Du, W., Hardouin, C., Cheng, H., Hwang, I., Cravatt, B. F., Boger, D. L. Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity Bioorganic & Medicinal Chemistry Letters  2005 15:1423-1428  DOI:10.1016/j.bmcl.2004.12.085  PMID:15713400
  • Du, W., Hardouin, C., Cheng, H., Hwang, I., Boger, D. L. Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase Bioorganic & Medicinal Chemistry Letters  2005 15:103-106  DOI:10.1016/j.bmcl.2004.10.025  PMID:15582420
  • Lee, P. S., Du, W., Boger, D. L., Jorgensen, W. L. Energetic preferences for alpha,beta versus beta,gamma unsaturation Journal of Organic Chemistry  2004 69:5448-5453  DOI:10.1021/jo049365y  PMID:15287795