Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Development of protein-detecting microarrays and related devices

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Kodadek, Thomas

publication date

  • June 2002

journal

  • Trends in Biochemical Sciences  Journal

abstract

  • There is great interest in the development of devices capable of monitoring the levels and post-translational modification states of hundreds or thousands of proteins simultaneously. One way to do this would be to create protein-detecting microarrays roughly akin to the DNA microarrays that are used for genome-wide expression studies. Two major challenges must be addressed before practical devices of this type become available. One is the development of high-throughput methods for the isolation of protein-binding compounds that will act as capture molecules in the array. The second is the optimization of methods that register binding of target proteins to the immobilized ligands in a sensitive and quantitative fashion. Progress in these areas, and some of the challenges remaining, are reviewed in this article.

subject areas

  • Antibodies
  • Equipment Design
  • Gene Expression Profiling
  • Humans
  • Ligands
  • Oligonucleotide Array Sequence Analysis
  • Peptide Mapping
  • Protein Binding
  • Protein Processing, Post-Translational
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/s0968-0004(02)02105-9

PubMed ID

  • 12069789
scroll to property group menus

Additional Document Info

start page

  • 295

end page

  • 300

volume

  • 27

issue

  • 6

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support