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Nonredundant roles of tirap and myd88 in airway response to endotoxin, independent of trif, il-1 and il-18 pathways

Academic Article
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Overview

authors

  • Togbe, D.
  • Aurore, G.
  • Noulin, N.
  • Quesniaux, V. F. J.
  • Schnyder-Candrian, S.
  • Schnyder, B.
  • Vasseur, V.
  • Akira, S.
  • Hoebe, K.
  • Beutler, Bruce
  • Ryffel, B.
  • Couillin, I.

publication date

  • November 2006

journal

  • Laboratory Investigation  Journal

abstract

  • Inhaled endotoxins induce an acute inflammatory response in the airways mediated through Toll-like receptor 4 (TLR4) and myeloid differentiation factor 88 (MyD88). However, the relative roles of the TLR4 adaptor proteins TIRAP and TRIF and of the MyD88-dependent IL-1 and IL-18 receptor pathways in this response are unclear. Here, we demonstrate that endotoxin-induced acute bronchoconstriction, vascular damage resulting in protein leak, Th1 cytokine and chemokine secretion and neutrophil recruitment in the airways are abrogated in mice deficient for either TIRAP or MyD88, but not in TRIF deficient mice. The contribution of other TLR-independent, MyD88-dependent signaling pathways was investigated in IL-1R1, IL-18R and caspase-1 (ICE)-deficient mice, which displayed normal airway responses to endotoxin. In conclusion, the TLR4-mediated, bronchoconstriction and acute inflammatory lung pathology to inhaled endotoxin critically depend on the expression of both adaptor proteins, TIRAP and MyD88, suggesting cooperative roles, while TRIF, IL-1R1, IL-18R signaling pathways are dispensable.

subject areas

  • Adaptor Proteins, Vesicular Transport
  • Animals
  • Bronchi
  • Bronchoalveolar Lavage Fluid
  • Bronchoconstriction
  • Cells, Cultured
  • Endotoxins
  • Interleukin-1
  • Interleukin-18
  • Lipopolysaccharides
  • Lung
  • Macrophages
  • Membrane Glycoproteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myeloid Differentiation Factor 88
  • Peroxidase
  • Receptors, Interleukin-1
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Research

keywords

  • TLR signaling
  • airways response
  • caspase-1
  • endotoxin
  • innate immunity
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Identity

International Standard Serial Number (ISSN)

  • 0023-6837

Digital Object Identifier (DOI)

  • 10.1038/labinvest.3700473

PubMed ID

  • 16983331
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Additional Document Info

start page

  • 1126

end page

  • 1135

volume

  • 86

issue

  • 11

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