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Protein sorting by directed maturation of golgi compartments

Academic Article
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Overview

authors

  • Allan, R. B.
  • Balch, William E.

publication date

  • July 1999

journal

  • Science  Journal

abstract

  • How does the Golgi stack mediate transport of cargo from the endoplasmic reticulum (ER) to the cell surface? A possibility is that cargo-containing vesicles derived from the ER form early Golgi compartments that then mature by retrieval of processing enzymes from later Golgi compartments. Maturation continues at terminal Golgi compartments by retrieval of transport components from the endocytic pathway to promote sorting of cargo to multiple cellular destinations. Hence, retrograde movement may integrate exocytic and endocytic pathways in eukaryotic cells and coordinate membrane flow and cargo transport through the Golgi stack.

subject areas

  • Animals
  • Biological Transport
  • Cell Membrane
  • Coated Vesicles
  • Coatomer Protein
  • Endocytosis
  • Endoplasmic Reticulum
  • Exocytosis
  • Golgi Apparatus
  • Membrane Proteins
  • Proteins
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

PubMed ID

  • 10390362
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Additional Document Info

start page

  • 63

end page

  • 66

volume

  • 285

issue

  • 5424

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