Cu(ii)-aza(bisoxazoline)-catalyzed asymmetric benzoylations

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Overview

authors

• Gissibl, A.
• Finn, M.G.
• Reiser, O.

publication date

• June 2005

journal

• Organic Letters  Journal

abstract

• [reaction: see text] Racemic 1,2-diols and alpha-hydroxy carbonyl compounds can be asymmetrically benzoylated in a kinetic resolution in the presence of various Cu(II)-aza(bisoxazoline) catalysts. A novel bisbenzyl-substituted aza(bisoxazoline) ligand proved to be especially effective when immobilized on MeOPEG(5000), giving from 91 to > or = 99% ee in 37-49% yield for each of five sequential reactions.

Identity

International Standard Serial Number (ISSN)

• 1523-7060

Digital Object Identifier (DOI)

• 10.1021/ol0505252

PubMed ID

• 15932189

Additional Document Info

start page

• 2325

end page

• 2328

volume

• 7

issue

• 12