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Fatty acid amide hydrolase: An emerging therapeutic target in the endocannabinoid system

Academic Article
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Overview

authors

  • Cravatt, Benjamin
  • Lichtman, A. H.

publication date

  • August 2003

journal

  • Current Opinion in Chemical Biology  Journal

abstract

  • The medicinal properties of exogenous cannabinoids have been recognized for centuries and can largely be attributed to the activation in the nervous system of a single G-protein-coupled receptor, CB1. However, the beneficial properties of cannabinoids, which include relief of pain and spasticity, are counterbalanced by adverse effects such as cognitive and motor dysfunction. The recent discoveries of anandamide, a natural lipid ligand for CB1, and an enzyme, fatty acid amide hydrolase (FAAH), that terminates anandamide signaling have inspired pharmacological strategies to augment endogenous cannabinoid ('endocannabinoid') activity with FAAH inhibitors, which might exhibit superior selectivity in their elicited behavioral effects compared with direct CB1 agonists.

subject areas

  • Amidohydrolases
  • Animals
  • Arachidonic Acids
  • Cannabinoid Receptor Modulators
  • Cannabinoids
  • Crystallography, X-Ray
  • Drug Delivery Systems
  • Drug Design
  • Endocannabinoids
  • Enzyme Inhibitors
  • Humans
  • Molecular Structure
  • Polyunsaturated Alkamides
  • Receptor, Cannabinoid, CB1
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Identity

International Standard Serial Number (ISSN)

  • 1367-5931

Digital Object Identifier (DOI)

  • 10.1016/s1367-5931(03)00079-6

PubMed ID

  • 12941421
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Additional Document Info

start page

  • 469

end page

  • 475

volume

  • 7

issue

  • 4

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