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Lateral mobility of human erythrocyte integral membrane proteins

Academic Article
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Overview

authors

  • Fowler, Velia
  • Branton, D.

publication date

  • 1977

journal

  • Nature  Journal

abstract

  • Fluorescein isothiocyanate-labelled integral membrane proteins are mobile in the membranes of human erythrocytes that have fused (and haemolysed) by Sendai virus or polyethylene glycol. Minimum diffusion coefficients are of the order of 10(-11) cm2 s-1 at 37 degrees C. This mobility is reduced several-fold at room temperature, not detected at 0 degrees C, and is significantly greater in fresh than in aged blood. Mobility was assessed by observing the spread of fluorescence on labelled cells which had been fused with unlabelled cells; neither intramembrane particle aggregation nor spectrin release occurred during this process.

subject areas

  • Adenosine Triphosphate
  • Cell Fusion
  • Cell Survival
  • Diffusion
  • Erythrocyte Membrane
  • Erythrocytes
  • Fluoresceins
  • Hemolysis
  • Humans
  • Hydrolysis
  • Membrane Proteins
  • Spectrin
  • Temperature
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Identity

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/268023a0

PubMed ID

  • 887143
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Additional Document Info

start page

  • 23

end page

  • 26

volume

  • 268

issue

  • 5615

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