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Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

Academic Article
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Overview

authors

  • Mosnier, Laurent
  • Griffin, John

publication date

  • July 2003

journal

  • Biochemical Journal  Journal

abstract

  • In a model of staurosporine-induced apoptosis using EAhy926 endothelial cells, inhibition of apoptosis by activated protein C was dose-dependent and required the enzyme's active site, implicating activated protein C-mediated proteolysis. Consistent with this implication, both protease-activated receptor-1 (PAR-1) and endothelial cell protein C receptor (EPCR) were required for the anti-apoptotic effects of activated protein C.

subject areas

  • Animals
  • Anticoagulants
  • Apoptosis
  • Blood Coagulation Factors
  • Cell Line
  • Endothelium, Vascular
  • Enzyme Inhibitors
  • Kinetics
  • Models, Biological
  • Protein Kinase C
  • Receptor, PAR-1
  • Receptors, Cell Surface
  • Receptors, Thrombin
  • Staurosporine
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Research

keywords

  • activated protein C
  • apoptosis
  • endothelial cell protein C receptor (EPCR)
  • protease-activated receptor (PAR)
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Identity

International Standard Serial Number (ISSN)

  • 0264-6021

Digital Object Identifier (DOI)

  • 10.1042/bj20030341

PubMed ID

  • 12683950
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Additional Document Info

start page

  • 65

end page

  • 70

volume

  • 373

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