Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Acamprosate and naltrexone treatment for alcohol dependence: an evidence-based risk-benefits assessment

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Mason, Barbara

publication date

  • December 2003

journal

  • European Neuropsychopharmacology  Journal

abstract

  • This paper provides an evidence-based risk-benefit assessment of acamprosate and naltrexone in the treatment of alcohol dependence. A risk-benefit assessment is based on the premise that the choice of treatment depends on a number of factors, notably the adverse event profile and efficacy. An evidence-based approach attempts to operationalize how such risk-benefit assessments are made to inform physician choices. This approach involves a systematic assessment of all published double-blind, placebo-controlled trials. Based on this review, we conclude acamprosate and naltrexone are both useful in the treatment of alcohol dependence. However, the two drugs act in different ways in the brain, and their clinical profiles are different. Treatment effects seem to be more reliable for acamprosate, and this drug is better tolerated. The safety of the two drugs in combination has been supported by two independent double-blind studies, and combination treatment may offer an advantage for some patients.

subject areas

  • Alcohol Deterrents
  • Alcoholism
  • Double-Blind Method
  • Drug Therapy, Combination
  • Evidence-Based Medicine
  • Humans
  • Naltrexone
  • Narcotic Antagonists
  • Randomized Controlled Trials as Topic
  • Taurine
scroll to property group menus

Research

keywords

  • acamprosate
  • alcohol dependence
  • naltrexone
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0924-977X

Digital Object Identifier (DOI)

  • 10.1016/j.euroneuro.2003.08.009

PubMed ID

  • 14636963
scroll to property group menus

Additional Document Info

start page

  • 469

end page

  • 475

volume

  • 13

issue

  • 6

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support