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Response artifact in the measurement of neuroleptic-induced anhedonia

Academic Article
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Overview

authors

  • Ettenberg, A.
  • Koob, George
  • Bloom, Floyd

publication date

  • 1981

journal

  • Science  Journal

abstract

  • Systemic administration of the neuroleptic drug alpha-flupenthixol attenuated lever-pressing behavior in rats responding for rewarding brain stimulation. The magnitude of this attenuation was dose-dependent and resembled the effects of reward reduction and termination. However, when the operant response requirements of the same rats were changed to nose poking, identical drug treatments produced relatively little attenuation in performance. These data do not support the belief that neuroleptics produce a general state of anhedonia. Rather, the apparent suppression of reinforced behaviors depends at least in part on the kinetic requirements of the response.

subject areas

  • Animals
  • Brain
  • Conditioning (Psychology)
  • Dose-Response Relationship, Drug
  • Electroshock
  • Flupenthixol
  • Male
  • Rats
  • Reward
  • Thioxanthenes
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.7244622

PubMed ID

  • 7244622
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Additional Document Info

start page

  • 357

end page

  • 359

volume

  • 213

issue

  • 4505

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