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Lysophosphatidic acid in vascular development and disease

Academic Article
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Overview

authors

  • Teo, S. T.
  • Yung, Y. C.
  • Herr, D. R.
  • Chun, Jerold

publication date

  • August 2009

journal

  • IUBMB Life  Journal

abstract

  • Lysophosphatidic acid (LPA) is a small signaling lipid that is capable of stimulating a plethora of different cellular responses through the activation of its family of cognate G protein-coupled receptors. LPA mediates a wide range of biological effects in many tissue types that have been recently reviewed; however, its effects on vasculature development and function have received comparatively less examination. In this review, literature on the actions of LPA in three main aspects of vascular development (vasculogenesis, angiogenesis, and vascular maturation) is discussed. In addition, evidence for the roles of LPA signaling in the formation of secondary vascular structures, such as the blood brain barrier, is considered, consistent with significant roles for LPA signaling in vascular development, function, and disease.

subject areas

  • Animals
  • Blood Vessels
  • Blood-Brain Barrier
  • Lysophospholipids
  • Mice
  • Mice, Knockout
  • Neovascularization, Physiologic
  • Receptors, G-Protein-Coupled
  • Signal Transduction
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Research

keywords

  • G protein-coupled receptors
  • angiogenesis
  • lysophosphatidic acid
  • vasculature development
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Identity

PubMed Central ID

  • PMC4307796

International Standard Serial Number (ISSN)

  • 1521-6543

Digital Object Identifier (DOI)

  • 10.1002/iub.220

PubMed ID

  • 19621353
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Additional Document Info

start page

  • 791

end page

  • 799

volume

  • 61

issue

  • 8

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