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Human nop5/nop58 is a component common to the box c/d small nucleolar ribonucleoproteins

Academic Article
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Overview

authors

  • Lyman, S. K.
  • Gerace, Larry
  • Baserga, S. J.

publication date

  • December 1999

journal

  • RNA-a Publication of the RNA Society  Journal

abstract

  • We have identified an apparent human homolog of the yeast Nop5/Nop58 protein. hNop5/Nop58 codes for a protein of predicted molecular weight 59.6 kDa and is 46.8% identical to Saccharomyces cerevisiae Nop5/Nop58. Immunofluorescent staining with antibodies against hNop5/Nop58 indicate that it is localized primarily to the nucleolus, and coimmunoprecipitation from nuclear extracts demonstrates that hNop5/Nop58 interacts with the box C/D family of snoRNAs. Thus, hNop5/Nop58 is a common component of the box C/D snoRNPs, and joins fibrillarin as the second such component identified and characterized in metazoans.

subject areas

  • Amino Acid Sequence
  • Animals
  • Cell Nucleolus
  • Cloning, Molecular
  • Conserved Sequence
  • HeLa Cells
  • Humans
  • Mice
  • Molecular Sequence Data
  • Molecular Weight
  • Nuclear Proteins
  • Rats
  • Recombinant Proteins
  • Ribonucleoproteins
  • Ribonucleoproteins, Small Nucleolar
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Sequence Alignment
  • Sequence Homology, Amino Acid
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Research

keywords

  • genomics
  • nucleolus
  • ribosome biogenesis
  • snoRNPs
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Identity

International Standard Serial Number (ISSN)

  • 1355-8382

Digital Object Identifier (DOI)

  • 10.1017/s1355838299991288

PubMed ID

  • 10606270
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Additional Document Info

start page

  • 1597

end page

  • 1604

volume

  • 5

issue

  • 12

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