Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Lysophospholipid receptors: signaling and biology

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Ishii, I.
  • Fukushima, N.
  • Ye, X. Q.
  • Chun, Jerold

publication date

  • 2004

journal

  • Annual Review of Biochemistry  Journal

abstract

  • Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis. These functions influence many biological processes that include neurogenesis, angiogenesis, wound healing, immunity, and carcinogenesis. In recent years, identification of multiple cognate G protein-coupled receptors has provided a mechanistic framework for understanding how LPs play such diverse roles. Generation of LP receptor-null animals has allowed rigorous examination of receptor-mediated physiological functions in vivo and has identified new functions for LP receptor signaling. Efforts to develop LP receptor subtype-specific agonists/antagonists are in progress and raise expectations for a growing collection of chemical tools and potential therapeutic compounds. The rapidly expanding literature on the LP receptors is herein reviewed.

subject areas

  • Animals
  • Cardiovascular System
  • Female
  • Humans
  • Immunity
  • Ligands
  • Lysophospholipids
  • Mice
  • Molecular Structure
  • Neovascularization, Physiologic
  • Nervous System
  • Ovarian Neoplasms
  • Phylogeny
  • Rats
  • Receptors, G-Protein-Coupled
  • Receptors, Lysophospholipid
  • Reproduction
  • Signal Transduction
  • Wound Healing
scroll to property group menus

Research

keywords

  • G protein-coupled receptor
  • LPA
  • S1P
  • lysophosphatidic acid
  • lysophosphatidylcholine
  • sphingosine I-phosphate
  • sphingosylphosphorylcholine
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0066-4154

Digital Object Identifier (DOI)

  • 10.1146/annurev.biochem.73.011303.073731

PubMed ID

  • 15189145
scroll to property group menus

Additional Document Info

start page

  • 321

end page

  • 354

volume

  • 73

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support