Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Serum transthyretin levels in senile systemic amyloidosis: Effects of age, gender and ethnicity

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Buxbaum, Joel
  • Koziol, James
  • Connors, L. H.

publication date

  • December 2008

journal

  • Amyloid-Journal of Protein Folding Disorders  Journal

abstract

  • Serum transthyretin (TTR) levels are reduced in familial amyloidotic polyneuropathy (FAP). A single study of patients with senile systemic amyloidosis (SSA) in Sweden found that those individuals also had a significantly lower mean serum TTR concentration than age- and gender-matched controls. To determine if the same phenomenon prevailed in an ethnically more heterogeneous population, we compared the serum TTR levels, as determined by ELISA, in 45 documented SSA patients with congestive heart failure, 20 AL patients with congestive heart failure and population controls. Serum TTR concentrations in the controls were influenced in a statistically significant manner by age, gender and ethnicity. Although it is unlikely that such differences are clinically relevant, they must be considered when assessing the meaning of serum TTR concentrations in any clinically defined population. The serum concentrations in patients with SSA did not differ from age, gender and ethnically matched controls or from a group of AL patients with significant clinical cardiac involvement. We also compared TTR concentrations in 12 African-Americans carrying the TTR V122I allele with those in 826 African-Americans who were homozygous wild type at the TTR locus. The TTR V122I carriers had significantly lower serum TTR concentrations than appropriate controls even though the majority of such individuals had not reached the age of clinical or anatomic risk, i.e. over 60. Thus, as in carriers of other TTR mutations the serum TTR level is lower than normal, despite having a much later appearance of clinical disease.

subject areas

  • African Americans
  • Age Factors
  • Aged
  • Alleles
  • Amyloidosis
  • Amyloidosis, Familial
  • Base Sequence
  • Case-Control Studies
  • DNA Primers
  • European Continental Ancestry Group
  • Female
  • Heart Failure
  • Heterozygote
  • Humans
  • Male
  • Middle Aged
  • Point Mutation
  • Prealbumin
  • Sex Characteristics
scroll to property group menus

Research

keywords

  • TTR V122I
  • Transthyretin
  • senile systemic amyloidosis
  • serum transthyretin
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 1350-6129

Digital Object Identifier (DOI)

  • 10.1080/13506120802525285

PubMed ID

  • 19065297
scroll to property group menus

Additional Document Info

start page

  • 255

end page

  • 261

volume

  • 15

issue

  • 4

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support