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Selective inactivation of opioid receptors in rat hippocampus demonstrates that dynorphin-a and dynorphin-b may act on mu-receptors in the ca1 region

Academic Article
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Overview

authors

  • Chavkin, C.
  • Henriksen, S. J.
  • Siggins, George
  • Bloom, Floyd

publication date

  • 1985

journal

  • Brain Research  Journal

abstract

  • Dynorphin-A1-17 and dynorphin-B increased the evoked response of hippocampal CA1 pyramidal cells, as did other opioids tested. Treatment of the hippocampal slice with beta-funaltrexamine, a mu-receptor selective antagonist, blocked the effects of normorphine, dynorphin-A and dynorphin-B, but did not change the response to D-Ala2, D-Leu5-enkephalin. The low potency of kappa selective agonists and the antagonism by beta-funaltrexamine of the dynorphins' effect indicate that kappa-opioid receptors may not be involved in these observed responses. Our data suggest that both mu- and delta-receptors are functionally represented and provide evidence that the dynorphins or their derivatives may also be agonists at the mu-receptor.

subject areas

  • Animals
  • Dynorphins
  • Endorphins
  • Hippocampus
  • In Vitro Techniques
  • Naltrexone
  • Rats
  • Receptors, Opioid
  • Receptors, Opioid, mu
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Identity

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(85)91565-3

PubMed ID

  • 2859095
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Additional Document Info

start page

  • 366

end page

  • 370

volume

  • 331

issue

  • 2

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