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Objective criteria for in-vitro responses in human tumor colony-forming assays

Academic Article
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Overview

authors

  • Koziol, James
  • Petkau, J.
  • Taetle, R.

publication date

  • October 1988

journal

  • Medical Decision Making  Journal

abstract

  • The application of rigorous statistical criteria to the design and analysis of in-vitro assay techniques can lead to more reliable assessments of their utility. The authors demonstrate that an objective criterion for in-vitro drug sensitivity would yield less pronounced false-negative error rates than a fixed-cutoff rule, and would therefore be more suitable for screening of putative chemotherapeutic agents.

subject areas

  • Colony-Forming Units Assay
  • Decision Theory
  • Dose-Response Relationship, Drug
  • False Negative Reactions
  • Humans
  • Models, Statistical
  • Predictive Value of Tests
  • Probability
  • Tumor Stem Cell Assay
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Identity

International Standard Serial Number (ISSN)

  • 0272-989X

Digital Object Identifier (DOI)

  • 10.1177/0272989x8800800411

PubMed ID

  • 3185182
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Additional Document Info

start page

  • 304

end page

  • 309

volume

  • 8

issue

  • 4

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