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Virus-like particles in MDCK cells persistently infected with Borna-disease virus

Academic Article
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Overview

authors

  • Compans, R. W.
  • Melsen, L. R.
  • de la Torre, Juan

publication date

  • September 1994

journal

  • Virus Research  Journal

abstract

  • A line of Madin Darby canine kidney (MDCK) cells persistently infected with Borna disease virus was examined by electron microscopy. Thin sections revealed the presence of intracytoplasmic virus-like particles ranging from 50-100 nm in diameter. Nuclei of the infected cells exhibited accumulation of electron-dense granular structures 15-18 nm in diameter. The intracytoplasmic particles were roughly spherical with a limiting membrane, suggesting the presence of a lipid-containing envelope. The internal structure consisted of strand-like material which in some cases was condensed underneath the envelope. The possible relationship of these particles to Borna disease virions is discussed.

subject areas

  • Animals
  • Borna disease virus
  • Cell Line
  • Cell Nucleus
  • Cytoplasm
  • Dogs
  • Epithelial Cells
  • Inclusion Bodies, Viral
  • Kidney
  • Microscopy, Electron
  • Virion
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Research

keywords

  • BORNA DISEASE
  • MADIN DARBY CANINE KIDNEY CELL
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Identity

International Standard Serial Number (ISSN)

  • 0168-1702

Digital Object Identifier (DOI)

  • 10.1016/0168-1702(94)90107-4

PubMed ID

  • 7985412
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Additional Document Info

start page

  • 261

end page

  • 268

volume

  • 33

issue

  • 3

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