recent publications

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  • Lin, Y. H., Chen, Y. C., Kao, T. Y., Lin, Y. C., Hsu, T. E., Wu, Y. C., Ja, W. W., Brummel, T. J., Kapahi, P., Yuh, C. H., Yu, L. K., Lin, Z. H., et al. Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans Aging Cell  2014 13:755-764  DOI:10.1111/acel.12232  PMID:24889782  PMCID:PMC4116436
  • Lin, Y. C., Happer, M., Elder, J. H. Selection of drug-resistant feline immunodeficiency virus (FIV) encoding FIV/HIV chimeric protease in the presence of HIV-specific protease inhibitors Journal of Virology  2013 87:8524-8534  DOI:10.1128/jvi.01240-13  PMID:23720716  PMCID:PMC3719837
  • Tiefenbrunn, T., Forli, S., Baksh, M. M., Chang, M. W., Happer, M., Lin, Y. C., Perryman, A. L., Rhee, J. K., Torbett, B. E., Olson, A. J., Elder, J. H., Finn, M. G., et al. Small molecule regulation of protein conformation by binding in the flap of HIV protease ACS Chemical Biology  2013 1223-1231  DOI:10.1021/cb300611p  PMID:23540839  PMCID:PMC3769432
  • Degner, S. C., Verma-Gaur, J., Wong, T. P., Bossen, C., Iverson, G. M., Torkamani, A., Vettermann, C., Lin, Y. C., Ju, Z. L., Schulz, D., Murre, C. S., Birshtein, B. K., et al. CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells Proceedings of the National Academy of Sciences of the United States of America  2011 108:9566-9571  DOI:10.1073/pnas.1019391108  PMID:21606361  PMCID:PMC3111298
  • Lin, Y. C., Perryman, A. L., Olson, A. J., Torbett, B. E., Elder, J. H., Stout, C. D. Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease Acta Crystallographica Section D-Biological Crystallography  2011 67:540-548  DOI:10.1107/s0907444911011681  PMID:21636894  PMCID:PMC3107052
  • Chang, S. H., Han, J. L., Tseng, S. Y., Lee, H. Y., Lin, C. W., Lin, Y. C., Jeng, W. Y., Wang, A. H. J., Wu, C. Y., Wong, C. H. Glycan array on aluminum oxide-coated glass slides through phosphonate chemistry Journal of the American Chemical Society  2010 132:13371-13380  DOI:10.1021/ja1046523  PMID:20822102
  • Chang, M. W., Giffin, M. J., Muller, R., Savage, J., Lin, Y. C., Hong, S., Jin, W., Whitby, L. R., Elder, J. H., Boger, D. L., Torbett, B. E. Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries Biochemical Journal  2010 429:527-532  DOI:10.1042/bj20091645  PMID:20507280  PMCID:PMC3084599
  • Lin, Y. C., Torbett, B. E., Elder, J. H. Generation of infectious feline immunodeficiency virus (FIV) encoding FIV/human immunodeficiency virus chimeric protease Journal of Virology  2010 84:6799-6809  DOI:10.1128/jvi.00294-10  PMID:20410281  PMCID:PMC2903298
  • Elder, J. H., Lin, Y. C., Fink, E., Grant, C. K. Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV Current HIV Research  2010 8:73-80  DOI:10.2174/157016210790416389  PMID:20210782  PMCID:PMC2853889
  • Liang, C. H., Wang, C. C., Lin, Y. C., Chen, C. H., Wong, C. H., Wu, C. Y. Iron oxide/gold core/shell nanoparticles for ultrasensitive detection of carbohydrate-protein interactions Analytical Chemistry  2009 81:7750-7756  DOI:10.1021/ac9012286  PMID:19689135
  • Giffin, M. J., Heaslet, H., Brik, A., Lin, Y. C., Cauvi, G., Wong, C. H., McRee, D. E., Elder, J. H., Stout, C. D., Torbett, B. E. A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant Journal of Medicinal Chemistry  2008 51:6263-6270  DOI:10.1021/jm800149m  PMID:18823110  PMCID:PMC2744648
  • Elder, J. H., Sundstrom, M., de Rozieres, S., de Parseval, A., Grant, C. K., Lin, Y. C. Molecular mechanisms of fiv infection Veterinary Immunology and Immunopathology  2008 123:3-13  DOI:10.1016/j.vetimm.2008.01.007  PMID:18289701  PMCID:PMC2409060
  • Heaslet, H., Rosenfeld, R., Giffin, M., Lin, Y. C., Tam, K., Torbett, B. E., Elder, J. H., McRee, D. E., Stout, C. D. Conformational flexibility in the flap domains of ligand-free HIV protease Acta Crystallographica Section D-Biological Crystallography  2007 63:866-875  DOI:10.1107/s0907444907029125  PMID:17642513
  • Heaslet, H., Lin, Y. C., Tam, K., Torbett, B. E., Elder, J. H., Stout, C. D. Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3 Retrovirology  2007 4:1  DOI:10.1186/1742-4690-4-1  PMID:17212810  PMCID:PMC1781954
  • Whiting, M., Tripp, J. C., Lin, Y. C., Lindstrom, W., Olson, A. J., Elder, J. H., Sharpless, K. B., Fokin, V. V. Rapid discovery and structure-activity profiling of novel inhibitors of human immunodeficiency virus type 1 protease enabled by the copper(I)-catalyzed synthesis of 1,2,3-triazoles and their further functionalization Journal of Medicinal Chemistry  2006 49:7697-7710  DOI:10.1021/jm060754+  PMID:17181152
  • Lin, Y. C., Brik, A., de Parseval, A., Tam, K., Torbett, B. E., Wong, C. H., Elder, J. H. Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system Journal of Virology  2006 80:7832-7843  DOI:10.1128/jvi.00374-06  PMID:16873240  PMCID:PMC1563824
  • Heaslet, H., Kutilek, V., Morris, G. M., Lin, Y. C., Elder, J. H., Torbett, B. E., Stout, C. D. Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3 Journal of Molecular Biology  2006 356:967-981  DOI:10.1016/j.jmb.2005.11.094  PMID:16403521
  • Liang, F. S., Brik, A., Lin, Y. C., Elder, J. H., Wong, C. H. Epoxide opening in water and screening in situ for rapid discovery of enzyme inhibitors in microtiter plates Bioorganic & Medicinal Chemistry  2006 14:1058-1062  DOI:10.1016/j.bmc.2005.09.026  PMID:16275107
  • Whiting, M., Muldoon, J., Lin, Y. C., Silverman, S. M., Lindstrom, W., Olson, A. J., Kolb, H. C., Finn, M. G., Sharpless, K. B., Elder, J. H., Fokin, V. V. Inhibitors of HIV-1 protease by using in situ click chemistry Angewandte Chemie-International Edition  2006 45:1435-1439  DOI:10.1002/anie.200502161  PMID:16425339
  • Brik, A., Alexandratos, J., Lin, Y. C., Elder, J. H., Olson, A. J., Wlodawer, A., Goodsell, D. S., Wong, C. H. 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors ChemBioChem  2005 6:1167-1169  DOI:10.1002/cbic.200500101  PMID:15934050
  • Huitron-Resendiz, S., de Rozieres, S., Sanchez-Alavez, M., Buhler, B., Lin, Y. C., Lerner, D. L., Henriksen, N. W., Burudi, M., Fox, H. S., Torbett, B. E., Henriksen, S., Elder, J. H. Resolution and prevention of feline immunodeficiency virus-induced neurological deficits by treatment with the protease inhibitor TL-3 Journal of Virology  2004 78:4525-4532  DOI:10.1128/jvi.78.9.4525-4532.2004  PMID:15078933  PMCID:PMC387718
  • de Rozieres, S., Swan, C. H., Sheeter, D. A., Clingerman, K. J., Lin, Y. C., Huitron-Resendiz, S., Henriksen, S., Torbett, B. E., Elder, J. H. Assessment of FIV-C infection of cats as a function of treatment with the protease inhibitor, TL-3 Retrovirology  2004 1:38  DOI:10.1186/1742-4690-1-38  PMID:15555065  PMCID:PMC535546
  • Brik, A., Muldoon, J., Lin, Y. C., Elder, J. H., Goodsell, D. S., Olson, A. J., Fokin, V. V., Sharpless, K. B., Wong, C. H. Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors ChemBioChem  2003 4:1246-1248  DOI:10.1002/cbic.200300724  PMID:14613121
  • Lin, Y. C., Beck, Z., Morris, G. M., Olson, A. J., Elder, J. H. Structural basis for distinctions between substrate and inhibitor specificities for feline immunodeficiency virus and human immunodeficiency virus proteases Journal of Virology  2003 77:6589-6600  DOI:10.1128/jvi.77.12.6589-6600.2003  PMID:12767979  PMCID:PMC156162
  • Brik, A., Lin, Y. C., Elder, J., Wong, C. H. A quick diversity-oriented amide-forming reaction to optimize p-subsite residues of hiv protease inhibitors Chemistry & Biology  2002 9:891-896  DOI:10.1016/s1074-5521(02)00184-9  PMID:12204688
  • Buhler, B., Lin, Y. C., Morris, G., Olson, A. J., Wong, C. H., Richman, D. D., Elder, J. H., Torbett, B. E. Viral evolution in response to the broad-based retroviral protease inhibitor TL-3 Journal of Virology  2001 75:9502-9508  DOI:10.1128/jvi.75.19.9502-9508.2001  PMID:11533212  PMCID:PMC114517
  • Le, V. D., Mak, C. C., Lin, Y. C., Elder, J. H., Wong, C. H. Structure-activity studies of fiv and hiv protease inhibitors containing allophenylnorstatine Bioorganic & Medicinal Chemistry  2001 9:1185-1195  DOI:10.1016/s0968-0896(00)00346-1  PMID:11377177
  • Mak, C. C., Le, V. D., Lin, Y. C., Elder, J. H., Wong, C. H. Design, synthesis, and biological evaluation of hiv/fiv protease inhibitors incorporating a conformationally constrained macrocycle with a small p3 ' residue Bioorganic & Medicinal Chemistry Letters  2001 11:219-222  DOI:10.1016/s0960-894x(00)00641-7  PMID:11206463
  • Lin, Y. C., Beck, Z., Le, V. D., Morris, G. M., Olson, A. J., Wong, C. H., Elder, J. H., Lee, T. Alteration of substrate and inhibitor specificity of feline immunodeficiency virus protease Journal of Virology  2000 74:4710-4720  DOI:10.1128/jvi.74.10.4710-4720.2000  PMID:10775609  PMCID:PMC111993
  • Lee, T. Y., Le, V. D., Lim, D. Y., Lin, Y. C., Morris, G. M., Wong, A. L., Olson, A. J., Elder, J. H., Wong, C. H. Development of a new type of protease inhibitors, efficacious against FIV and HIV variants Journal of the American Chemical Society  1999 121:1145-1155  DOI:10.1021/ja982893p
  • Defrees, S. A., Gaeta, F. C. A., Lin, Y. C., Ichikawa, Y., Wong, C. H. Ligand recognition by e-selectin - analysis of conformation and activity of synthetic monomeric and bivalent sialyl lewis-x analogs Journal of the American Chemical Society  1993 115:7549-7550  DOI:10.1021/ja00069a083
  • Wong, C. H., Ichikawa, Y., Kajimoto, T., Liu, K. K. C., Shen, G. J., Lin, C. H., Wang, Y. F., Dumas, D. P., Lin, Y. C., Wang, R., Look, G. C. Practical synthesis of carbohydrates based on aldolases and glycosyl transferases Pure and Applied Chemistry  1993 65:803-808  DOI:10.1351/pac199365040803
  • Ichikawa, Y., Lin, Y. C., Dumas, D. P., Shen, G. J., Garciajunceda, E., Williams, M. A., Bayer, R., Ketcham, C., Walker, L. E., Paulson, J. C., Wong, C. H. Chemical-enzymatic synthesis and conformational-analysis of sialyl lewis-x and derivatives Journal of the American Chemical Society  1992 114:9283-9298  DOI:10.1021/ja00050a007
  • Lin, Y. C., Hummel, C. W., Huang, D. H., Ichikawa, Y., Nicolaou, K. C., Wong, C. H. Conformational studies of sialyl lewis-x in aqueous-solution Journal of the American Chemical Society  1992 114:5452-5454  DOI:10.1021/ja00039a082