recent publications
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academic article
- Lin, Y. H., Chen, Y. C., Kao, T. Y., Lin, Y. C., Hsu, T. E., Wu, Y. C., Ja, W. W., Brummel, T. J., Kapahi, P., Yuh, C. H., Yu, L. K., Lin, Z. H., et al. Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans Aging Cell 2014 13:755-764 DOI:10.1111/acel.12232 PMID:24889782 PMCID:PMC4116436
- Lin, Y. C., Happer, M., Elder, J. H. Selection of drug-resistant feline immunodeficiency virus (FIV) encoding FIV/HIV chimeric protease in the presence of HIV-specific protease inhibitors Journal of Virology 2013 87:8524-8534 DOI:10.1128/jvi.01240-13 PMID:23720716 PMCID:PMC3719837
- Tiefenbrunn, T., Forli, S., Baksh, M. M., Chang, M. W., Happer, M., Lin, Y. C., Perryman, A. L., Rhee, J. K., Torbett, B. E., Olson, A. J., Elder, J. H., Finn, M. G., et al. Small molecule regulation of protein conformation by binding in the flap of HIV protease ACS Chemical Biology 2013 1223-1231 DOI:10.1021/cb300611p PMID:23540839 PMCID:PMC3769432
- Degner, S. C., Verma-Gaur, J., Wong, T. P., Bossen, C., Iverson, G. M., Torkamani, A., Vettermann, C., Lin, Y. C., Ju, Z. L., Schulz, D., Murre, C. S., Birshtein, B. K., et al. CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells Proceedings of the National Academy of Sciences of the United States of America 2011 108:9566-9571 DOI:10.1073/pnas.1019391108 PMID:21606361 PMCID:PMC3111298
- Lin, Y. C., Perryman, A. L., Olson, A. J., Torbett, B. E., Elder, J. H., Stout, C. D. Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease Acta Crystallographica Section D-Biological Crystallography 2011 67:540-548 DOI:10.1107/s0907444911011681 PMID:21636894 PMCID:PMC3107052
- Chang, S. H., Han, J. L., Tseng, S. Y., Lee, H. Y., Lin, C. W., Lin, Y. C., Jeng, W. Y., Wang, A. H. J., Wu, C. Y., Wong, C. H. Glycan array on aluminum oxide-coated glass slides through phosphonate chemistry Journal of the American Chemical Society 2010 132:13371-13380 DOI:10.1021/ja1046523 PMID:20822102
- Chang, M. W., Giffin, M. J., Muller, R., Savage, J., Lin, Y. C., Hong, S., Jin, W., Whitby, L. R., Elder, J. H., Boger, D. L., Torbett, B. E. Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries Biochemical Journal 2010 429:527-532 DOI:10.1042/bj20091645 PMID:20507280 PMCID:PMC3084599
- Lin, Y. C., Torbett, B. E., Elder, J. H. Generation of infectious feline immunodeficiency virus (FIV) encoding FIV/human immunodeficiency virus chimeric protease Journal of Virology 2010 84:6799-6809 DOI:10.1128/jvi.00294-10 PMID:20410281 PMCID:PMC2903298
- Elder, J. H., Lin, Y. C., Fink, E., Grant, C. K. Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV Current HIV Research 2010 8:73-80 DOI:10.2174/157016210790416389 PMID:20210782 PMCID:PMC2853889
- Liang, C. H., Wang, C. C., Lin, Y. C., Chen, C. H., Wong, C. H., Wu, C. Y. Iron oxide/gold core/shell nanoparticles for ultrasensitive detection of carbohydrate-protein interactions Analytical Chemistry 2009 81:7750-7756 DOI:10.1021/ac9012286 PMID:19689135
- Giffin, M. J., Heaslet, H., Brik, A., Lin, Y. C., Cauvi, G., Wong, C. H., McRee, D. E., Elder, J. H., Stout, C. D., Torbett, B. E. A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant Journal of Medicinal Chemistry 2008 51:6263-6270 DOI:10.1021/jm800149m PMID:18823110 PMCID:PMC2744648
- Elder, J. H., Sundstrom, M., de Rozieres, S., de Parseval, A., Grant, C. K., Lin, Y. C. Molecular mechanisms of fiv infection Veterinary Immunology and Immunopathology 2008 123:3-13 DOI:10.1016/j.vetimm.2008.01.007 PMID:18289701 PMCID:PMC2409060
- Heaslet, H., Rosenfeld, R., Giffin, M., Lin, Y. C., Tam, K., Torbett, B. E., Elder, J. H., McRee, D. E., Stout, C. D. Conformational flexibility in the flap domains of ligand-free HIV protease Acta Crystallographica Section D-Biological Crystallography 2007 63:866-875 DOI:10.1107/s0907444907029125 PMID:17642513
- Heaslet, H., Lin, Y. C., Tam, K., Torbett, B. E., Elder, J. H., Stout, C. D. Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3 Retrovirology 2007 4:1 DOI:10.1186/1742-4690-4-1 PMID:17212810 PMCID:PMC1781954
- Whiting, M., Tripp, J. C., Lin, Y. C., Lindstrom, W., Olson, A. J., Elder, J. H., Sharpless, K. B., Fokin, V. V. Rapid discovery and structure-activity profiling of novel inhibitors of human immunodeficiency virus type 1 protease enabled by the copper(I)-catalyzed synthesis of 1,2,3-triazoles and their further functionalization Journal of Medicinal Chemistry 2006 49:7697-7710 DOI:10.1021/jm060754+ PMID:17181152
- Lin, Y. C., Brik, A., de Parseval, A., Tam, K., Torbett, B. E., Wong, C. H., Elder, J. H. Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system Journal of Virology 2006 80:7832-7843 DOI:10.1128/jvi.00374-06 PMID:16873240 PMCID:PMC1563824
- Heaslet, H., Kutilek, V., Morris, G. M., Lin, Y. C., Elder, J. H., Torbett, B. E., Stout, C. D. Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3 Journal of Molecular Biology 2006 356:967-981 DOI:10.1016/j.jmb.2005.11.094 PMID:16403521
- Liang, F. S., Brik, A., Lin, Y. C., Elder, J. H., Wong, C. H. Epoxide opening in water and screening in situ for rapid discovery of enzyme inhibitors in microtiter plates Bioorganic & Medicinal Chemistry 2006 14:1058-1062 DOI:10.1016/j.bmc.2005.09.026 PMID:16275107
- Whiting, M., Muldoon, J., Lin, Y. C., Silverman, S. M., Lindstrom, W., Olson, A. J., Kolb, H. C., Finn, M. G., Sharpless, K. B., Elder, J. H., Fokin, V. V. Inhibitors of HIV-1 protease by using in situ click chemistry Angewandte Chemie-International Edition 2006 45:1435-1439 DOI:10.1002/anie.200502161 PMID:16425339
- Brik, A., Alexandratos, J., Lin, Y. C., Elder, J. H., Olson, A. J., Wlodawer, A., Goodsell, D. S., Wong, C. H. 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors ChemBioChem 2005 6:1167-1169 DOI:10.1002/cbic.200500101 PMID:15934050
- Huitron-Resendiz, S., de Rozieres, S., Sanchez-Alavez, M., Buhler, B., Lin, Y. C., Lerner, D. L., Henriksen, N. W., Burudi, M., Fox, H. S., Torbett, B. E., Henriksen, S., Elder, J. H. Resolution and prevention of feline immunodeficiency virus-induced neurological deficits by treatment with the protease inhibitor TL-3 Journal of Virology 2004 78:4525-4532 DOI:10.1128/jvi.78.9.4525-4532.2004 PMID:15078933 PMCID:PMC387718
- de Rozieres, S., Swan, C. H., Sheeter, D. A., Clingerman, K. J., Lin, Y. C., Huitron-Resendiz, S., Henriksen, S., Torbett, B. E., Elder, J. H. Assessment of FIV-C infection of cats as a function of treatment with the protease inhibitor, TL-3 Retrovirology 2004 1:38 DOI:10.1186/1742-4690-1-38 PMID:15555065 PMCID:PMC535546
- Brik, A., Muldoon, J., Lin, Y. C., Elder, J. H., Goodsell, D. S., Olson, A. J., Fokin, V. V., Sharpless, K. B., Wong, C. H. Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors ChemBioChem 2003 4:1246-1248 DOI:10.1002/cbic.200300724 PMID:14613121
- Lin, Y. C., Beck, Z., Morris, G. M., Olson, A. J., Elder, J. H. Structural basis for distinctions between substrate and inhibitor specificities for feline immunodeficiency virus and human immunodeficiency virus proteases Journal of Virology 2003 77:6589-6600 DOI:10.1128/jvi.77.12.6589-6600.2003 PMID:12767979 PMCID:PMC156162
- Brik, A., Lin, Y. C., Elder, J., Wong, C. H. A quick diversity-oriented amide-forming reaction to optimize p-subsite residues of hiv protease inhibitors Chemistry & Biology 2002 9:891-896 DOI:10.1016/s1074-5521(02)00184-9 PMID:12204688
- Buhler, B., Lin, Y. C., Morris, G., Olson, A. J., Wong, C. H., Richman, D. D., Elder, J. H., Torbett, B. E. Viral evolution in response to the broad-based retroviral protease inhibitor TL-3 Journal of Virology 2001 75:9502-9508 DOI:10.1128/jvi.75.19.9502-9508.2001 PMID:11533212 PMCID:PMC114517
- Le, V. D., Mak, C. C., Lin, Y. C., Elder, J. H., Wong, C. H. Structure-activity studies of fiv and hiv protease inhibitors containing allophenylnorstatine Bioorganic & Medicinal Chemistry 2001 9:1185-1195 DOI:10.1016/s0968-0896(00)00346-1 PMID:11377177
- Mak, C. C., Le, V. D., Lin, Y. C., Elder, J. H., Wong, C. H. Design, synthesis, and biological evaluation of hiv/fiv protease inhibitors incorporating a conformationally constrained macrocycle with a small p3 ' residue Bioorganic & Medicinal Chemistry Letters 2001 11:219-222 DOI:10.1016/s0960-894x(00)00641-7 PMID:11206463
- Lin, Y. C., Beck, Z., Le, V. D., Morris, G. M., Olson, A. J., Wong, C. H., Elder, J. H., Lee, T. Alteration of substrate and inhibitor specificity of feline immunodeficiency virus protease Journal of Virology 2000 74:4710-4720 DOI:10.1128/jvi.74.10.4710-4720.2000 PMID:10775609 PMCID:PMC111993
- Lee, T. Y., Le, V. D., Lim, D. Y., Lin, Y. C., Morris, G. M., Wong, A. L., Olson, A. J., Elder, J. H., Wong, C. H. Development of a new type of protease inhibitors, efficacious against FIV and HIV variants Journal of the American Chemical Society 1999 121:1145-1155 DOI:10.1021/ja982893p
- Defrees, S. A., Gaeta, F. C. A., Lin, Y. C., Ichikawa, Y., Wong, C. H. Ligand recognition by e-selectin - analysis of conformation and activity of synthetic monomeric and bivalent sialyl lewis-x analogs Journal of the American Chemical Society 1993 115:7549-7550 DOI:10.1021/ja00069a083
- Wong, C. H., Ichikawa, Y., Kajimoto, T., Liu, K. K. C., Shen, G. J., Lin, C. H., Wang, Y. F., Dumas, D. P., Lin, Y. C., Wang, R., Look, G. C. Practical synthesis of carbohydrates based on aldolases and glycosyl transferases Pure and Applied Chemistry 1993 65:803-808 DOI:10.1351/pac199365040803
- Ichikawa, Y., Lin, Y. C., Dumas, D. P., Shen, G. J., Garciajunceda, E., Williams, M. A., Bayer, R., Ketcham, C., Walker, L. E., Paulson, J. C., Wong, C. H. Chemical-enzymatic synthesis and conformational-analysis of sialyl lewis-x and derivatives Journal of the American Chemical Society 1992 114:9283-9298 DOI:10.1021/ja00050a007
- Lin, Y. C., Hummel, C. W., Huang, D. H., Ichikawa, Y., Nicolaou, K. C., Wong, C. H. Conformational studies of sialyl lewis-x in aqueous-solution Journal of the American Chemical Society 1992 114:5452-5454 DOI:10.1021/ja00039a082