Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Somatic recombination in a murine t-cell receptor gene

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Chien, Y. H.
  • Gascoigne, Nicholas
  • Kavaler, J.
  • Lee, N. E.
  • Davis, M. M.

publication date

  • 1984

journal

  • Nature  Journal

abstract

  • A putative T-cell receptor gene was isolated from the DNA of the helper hybridoma, 2B4 . Analysis of the sequence components of this rearranged gene indicates the presence of separate variable (V), diversity (D) and joining (J) region elements analogous to those of heavy-chain immunoglobulins. These findings further support the belief that the products of this locus are involved in antigen recognition by T cells. There is no evidence of somatic mutation between the putative germ-line and the expressed variable-region gene.

subject areas

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA
  • DNA Restriction Enzymes
  • Genes
  • Hybridomas
  • Immunoglobulin J-Chains
  • Immunoglobulin Variable Region
  • Mice
  • RNA, Messenger
  • Receptors, Antigen, T-Cell
  • T-Lymphocytes
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/309322a0

PubMed ID

  • 6328306
scroll to property group menus

Additional Document Info

start page

  • 322

end page

  • 326

volume

  • 309

issue

  • 5966

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support