recent publications
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academic article
- Vale, C., Nicolaou, K. C., Frederick, M. O., Vieytes, M. R., Botana, L. M. Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-jun-n-terminal kinase activation in cultured neurons Toxicological Sciences 2010 113:158-168 DOI:10.1093/toxsci/kfp246 PMID:19815690 PMCID:PMC2794333
- Vale, C., Wandscheer, C., Nicolaou, K. C., Frederick, M. O., Alfonso, C., Vieytes, M. R., Botana, L. M. Cytotoxic effect of azaspiracid-2 and azaspiracid-2-methyl ester in cultured neurons: Involvement of the c-jun n-terminal kinase Journal of Neuroscience Research 2008 86:2952-2962 DOI:10.1002/jnr.21731 PMID:18500761
- Vilarino, N., Nicolaou, K. C., Frederick, M. O., Cagide, E., Alfonso, C., Alonso, E., Vieytes, M. R., Botana, L. M. Azaspiracid substituent at c1 is relevant to in vitro toxicity Chemical Research in Toxicology 2008 21:1823-1831 DOI:10.1021/tx800165c PMID:18707138 PMCID:PMC2559976
- Vilarino, N., Nicolaou, K. C., Frederick, M. O., Vieytes, M. R., Botana, L. M. Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells Biochemical Pharmacology 2007 74:327-335 DOI:10.1016/j.bcp.2007.04.004 PMID:17485074
- Vale, C., Nicolaou, K. C., Frederick, M. O., Gomez-Limia, B., Alfonso, A., Vieytes, M. R., Botana, L. M. Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study Journal of Medicinal Chemistry 2007 50:356-363 DOI:10.1021/jm061063g PMID:17228878
- Vale, C., Gomez-Limia, B., Nicolaou, K. C., Frederick, M. O., Vieytes, M. R., Botana, L. M. The c-jun-n-terminal kinase is involved in the neurotoxic effect of azaspiracid-1 Cellular Physiology and Biochemistry 2007 20:957-966 DOI:10.1159/000110457 PMID:17982278
- Vilarino, N., Nicolaou, K. C., Frederick, M. O., Cagide, E., Ares, I. R., Louzao, M. C., Vieytes, M. R., Botana, L. M. Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies Chemical Research in Toxicology 2006 19:1459-1466 DOI:10.1021/tx060131z PMID:17112233
- Alfonso, A., Vieytes, M. R., Ofuji, K., Satake, M., Nicolaou, K. C., Frederick, M. O., Botana, L. M. Azaspiracids modulate intracellular ph levels in human lymphocytes Biochemical and Biophysical Research Communications 2006 346:1091-1099 DOI:10.1016/j.bbrc.2006.06.019 PMID:16793022