recent publications

• academic article

  • Vale, C., Nicolaou, K. C., Frederick, M. O., Vieytes, M. R., Botana, L. M. Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-jun-n-terminal kinase activation in cultured neurons Toxicological Sciences  2010 113:158-168  DOI:10.1093/toxsci/kfp246  PMID:19815690  PMCID:PMC2794333
  • Vale, C., Wandscheer, C., Nicolaou, K. C., Frederick, M. O., Alfonso, C., Vieytes, M. R., Botana, L. M. Cytotoxic effect of azaspiracid-2 and azaspiracid-2-methyl ester in cultured neurons: Involvement of the c-jun n-terminal kinase Journal of Neuroscience Research  2008 86:2952-2962  DOI:10.1002/jnr.21731  PMID:18500761
  • Vilarino, N., Nicolaou, K. C., Frederick, M. O., Cagide, E., Alfonso, C., Alonso, E., Vieytes, M. R., Botana, L. M. Azaspiracid substituent at c1 is relevant to in vitro toxicity Chemical Research in Toxicology  2008 21:1823-1831  DOI:10.1021/tx800165c  PMID:18707138  PMCID:PMC2559976
  • Vilarino, N., Nicolaou, K. C., Frederick, M. O., Vieytes, M. R., Botana, L. M. Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells Biochemical Pharmacology  2007 74:327-335  DOI:10.1016/j.bcp.2007.04.004  PMID:17485074
  • Vale, C., Nicolaou, K. C., Frederick, M. O., Gomez-Limia, B., Alfonso, A., Vieytes, M. R., Botana, L. M. Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study Journal of Medicinal Chemistry  2007 50:356-363  DOI:10.1021/jm061063g  PMID:17228878
  • Vale, C., Gomez-Limia, B., Nicolaou, K. C., Frederick, M. O., Vieytes, M. R., Botana, L. M. The c-jun-n-terminal kinase is involved in the neurotoxic effect of azaspiracid-1 Cellular Physiology and Biochemistry  2007 20:957-966  DOI:10.1159/000110457  PMID:17982278
  • Vilarino, N., Nicolaou, K. C., Frederick, M. O., Cagide, E., Ares, I. R., Louzao, M. C., Vieytes, M. R., Botana, L. M. Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies Chemical Research in Toxicology  2006 19:1459-1466  DOI:10.1021/tx060131z  PMID:17112233
  • Alfonso, A., Vieytes, M. R., Ofuji, K., Satake, M., Nicolaou, K. C., Frederick, M. O., Botana, L. M. Azaspiracids modulate intracellular ph levels in human lymphocytes Biochemical and Biophysical Research Communications  2006 346:1091-1099  DOI:10.1016/j.bbrc.2006.06.019  PMID:16793022