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cdc25+ functions as an inducer in the mitotic control of fission yeast

Academic Article
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Overview

authors

  • Russell, Paul
  • Nurse, P.

publication date

  • April 1986

journal

  • Cell  Journal

abstract

  • In the fission yeast S. pombe the cdc25+ gene function is required to initiate mitosis. We have cloned the cdc25+ gene and have found that increased cdc25+ expression causes mitosis to initiate at a reduced cell size. This shows that cdc25+ functions as a dosage-dependent inducer in mitotic control, the first such mitotic control element to be specifically identified. DNA sequencing of the cdc25+ gene has shown that it can encode a protein of MW 67,000. Evidence is described showing that cdc25+ functions to counteract the activity of the mitotic inhibitor wee1+, and indicating that both mitotic control elements act independently to regulate the initiation of mitosis.

subject areas

  • Base Sequence
  • Cell Cycle
  • Cloning, Molecular
  • Gene Expression Regulation
  • Genes, Fungal
  • Mitosis
  • Saccharomycetales
  • Schizosaccharomyces
  • Time Factors
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(86)90546-5

PubMed ID

  • 3955656
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Additional Document Info

start page

  • 145

end page

  • 153

volume

  • 45

issue

  • 1

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