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Distinct footprints of tcr engagement with highly homologous ligands

Academic Article
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Overview

authors

  • Santori, F. R.
  • Holmberg, K.
  • Ostrov, D.
  • Gascoigne, Nicholas
  • Vukmanovic, S.

publication date

  • June 2004

journal

  • Journal of Immunology  Journal

abstract

  • T cell receptor engagement promotes proliferation, differentiation, survival, or death of T lymphocytes. The affinity/avidity of the TCR ligand and the maturational stage of the T cell are thought to be principal determinants of the outcome of TCR engagement. We demonstrate in this study that the same mouse TCR preferentially uses distinct residues of homologous peptides presented by the MHC molecules to promote specific cellular responses. The preference for distinct TCR contacts depends on neither the affinity/avidity of TCR engagement (except in the most extreme ranges), nor the maturity of engaged T cells. Thus, different portions of the TCR ligand appear capable of biasing T cells toward specific biological responses. These findings explain differences in functional versatility of TCR ligands, as well as anomalies in the relationship between affinity/avidity of the TCR for the peptide/MHC and cellular responses of T cells.

subject areas

  • Amino Acid Sequence
  • Animals
  • Antigen Presentation
  • Epitope Mapping
  • Epitopes, T-Lymphocyte
  • Ligands
  • Mice
  • Mice, Transgenic
  • Models, Molecular
  • Peptides
  • Protein Binding
  • Protein Footprinting
  • Receptors, Antigen, T-Cell
  • Structure-Activity Relationship
  • T-Lymphocyte Subsets
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 15187125
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Additional Document Info

start page

  • 7466

end page

  • 7475

volume

  • 172

issue

  • 12

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