recent publications
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academic article
- Teh, C. E., Horikawa, K., Arnold, C. N., Beutler, B., Kucharska, E. M., Vinuesa, C. G., Bertram, E. M., Goodnow, C. C., Enders, A. Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation Genes and Immunity 2013 14:223-233 DOI:10.1038/gene.2013.11 PMID:23552399 PMCID:PMC3676473
- Arnold, C. N., Pirie, E., Dosenovic, P., McInerney, G. M., Xia, Y., Wang, N., Li, X. H., Siggs, O. M., Hedestam, G. B. K., Beutler, B. A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity Proceedings of the National Academy of Sciences of the United States of America 2012 109:12286-12293 DOI:10.1073/pnas.1209134109 PMID:22761313 PMCID:PMC3411946
- Arnold, C. N., Barnes, M. J., Berger, M., Blasius, A. L., Brandl, K., Croker, B., Crozat, K., Du, X., Eidenschenk, C., Georgel, P., Hoebe, K., Huang, H., et al. ENU-induced phenovariance in mice: Inferences from 587 mutations BMC Research Notes 2012 5:577 DOI:10.1186/1756-0500-5-577 PMID:23095377 PMCID:PMC3532239
- Won, S., Eidenschenk, C., Arnold, C. N., Siggs, O. M., Sun, L., Brandl, K., Mullen, T. M., Nemerow, G. R., Moresco, E. M. Y., Beutler, B. Increased susceptibility to DNA virus infection in mice with a GCN2 mutation Journal of Virology 2012 86:1802-1808 DOI:10.1128/jvi.05660-11 PMID:22114338 PMCID:PMC3264364
- Arnold, C. N., Xia, Y., Lin, P., Ross, C., Schwander, M., Smart, N. G., Muller, U., Beutler, B. Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis Genetics 2011 187:633-641 DOI:10.1534/genetics.110.124586 PMID:21196518 PMCID:PMC3063661
- Siggs, O. M., Arnold, C. N., Huber, C., Pirie, E., Xia, Y., Lin, P., Nemazee, D., Beutler, B. The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow Nature Immunology 2011 12:434-440 DOI:10.1038/ni.2012 PMID:21423172 PMCID:PMC3079768
- Siggs, O. M., Berger, M., Krebs, P., Arnold, C. N., Eidenschenk, C., Huber, C., Pirie, E., Smart, N. G., Khovananth, K., Xia, Y., McInerney, G., Hedestam, G. B. K., et al. A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα Proceedings of the National Academy of Sciences of the United States of America 2010 107:3046-3051 DOI:10.1073/pnas.0915098107 PMID:20133626 PMCID:PMC2840324
- Eidenschenk, C., Crozat, K., Krebs, P., Arens, R., Popkin, D., Arnold, C. N., Blasius, A. L., Benedict, C. A., Moresco, E. M. Y., Xia, Y., Beutler, B. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells Proceedings of the National Academy of Sciences of the United States of America 2010 107:9759-9764 DOI:10.1073/pnas.1005186107 PMID:20457904 PMCID:PMC2906899
- Barnes, M. J., Aksoylar, H., Krebs, P., Bourdeau, T., Arnold, C. N., Xia, Y., Khovananth, K., Engel, I., Sovath, S., Lampe, K., Laws, E., Saunders, A., et al. Loss of t cell and b cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in gimap5-deficient mice Journal of Immunology 2010 184:3743-3754 DOI:10.4049/jimmunol.0903164 PMID:20190135 PMCID:PMC4395861
- Blasius, A. L., Arnold, C. N., Georgel, P., Rutschmann, S., Xia, Y., Lin, P., Ross, C., Li, X. H., Smart, N. G., Beutler, B. Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells Proceedings of the National Academy of Sciences of the United States of America 2010 107:19973-19978 DOI:10.1073/pnas.1014051107 PMID:21045126 PMCID:PMC2993408
- Barnes, M. J., Krebs, P., Harris, N., Eidenschenk, C., Gonzalez-Quintial, R., Arnold, C. N., Crozat, K., Sovath, S., Moresco, E. M., Theofilopoulos, A. N., Beutler, B., Hoebe, K. Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery PLoS Biology 2009 7:e1000051 DOI:10.1371/journal.pbio.1000051 PMID:19260764 PMCID:PMC2650725
- Kono, D. H., Haraldsson, M. K., Lawson, B. R., Pollard, K. M., Koh, Y. T., Du, X., Arnold, C. N., Baccala, R., Silverman, G. J., Beutler, B. A., Theofilopoulos, A. N. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus Proceedings of the National Academy of Sciences of the United States of America 2009 106:12061-12066 DOI:10.1073/pnas.0905441106 PMID:19574451 PMCID:PMC2715524