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Bovine spongiform encephalopathy and early onset variant Creutzfeldt-Jakob disease

Academic Article
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Overview

authors

  • Weissmann, Charles
  • Aguzzi, A.

publication date

  • October 1997

journal

  • Current Opinion in Neurobiology  Journal

abstract

  • Transmissible spongiform encephalopathies affect a variety of vertebrates, including humans. While scrapie has been enzootic in sheep for centuries, bovine spongiform encephalopathy (BSE) appeared only some 12 years ago but rapidly became epizootic. It is not clear whether BSE originated in cattle as a rare spontaneous event or whether it stems from sheep, but its spread is clearly due to feeding of cattle-derived contaminated bone and meat meal. Recent evidence links the appearance of new variant Creutzfeldt-Jakob disease in humans to consumption of BSE-contaminated cattle-derived products.

subject areas

  • Animals
  • Cattle
  • Creutzfeldt-Jakob Syndrome
  • Encephalopathy, Bovine Spongiform
  • Humans
  • PrPSc Proteins
  • Prion Diseases
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Identity

International Standard Serial Number (ISSN)

  • 0959-4388

Digital Object Identifier (DOI)

  • 10.1016/s0959-4388(97)80091-8

PubMed ID

  • 9384548
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Additional Document Info

start page

  • 695

end page

  • 700

volume

  • 7

issue

  • 5

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