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Role of a nonimmunoglobulin cell surface determinant in the activation of B lymphocytes by thymus-independent antigens

Academic Article
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Overview

authors

  • Subbarao, B.
  • Mosier, Donald
  • Ahmed, A.
  • Mond, J. J.
  • Scher, I.
  • Paul, W. E.

publication date

  • 1979

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Lyb 5 is a B-cell alloantigen which is expressed on 50-60% of B cells. It was defined originally on the basis of cytotoxicity. We have described a new reactivity within the anti-Lyb 5 serum on the basis of selective inhibition of antibody responses in vitro by this antiserum in the absence of complement. This inhibitory activity of anti-Lyb 5.1 serum appears to be due to recognition of antigenic determinants different from the prototype antigens detected in the cytotoxicity assay. Anti-Lyb 5 serum incorporated into spleen cell cultures selectively inhibits antibody responses to a class of thymus-independent antigens (TI-2) previously characterized by their failure to elicit antibody formation in immature mice or in the defective CBA/N strain. Responses to optimal concentrations of TI-1 antigens, which can induce antibody synthesis in these mice, are unaffected by the addition of anti-Lyb 5.1 serum. The B-cell alloantigen defined by this functional assay is designated tentatively Lyb 7 and it is shown to be distinct from cell surface immunoglobulins. Lyb 7 appears to have a role in the activation of B lymphocytes by the TI-2 class of thymus-independent antigens.

subject areas

  • Antibody Formation
  • Antigen-Antibody Reactions
  • Antigens, Surface
  • B-Lymphocytes
  • Cells, Cultured
  • Dextrans
  • Epitopes
  • Ficoll
  • Isoantibodies
  • Isoantigens
  • Lymphocyte Activation
  • Trinitrobenzenes
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Identity

PubMed Central ID

  • PMC2184815

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.149.2.495

PubMed ID

  • 84046
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Additional Document Info

start page

  • 495

end page

  • 506

volume

  • 149

issue

  • 2

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