Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Transport and secretion of truncated t-cell receptor beta-chain occurs in the absence of association with cd3

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Gascoigne, Nicholas

publication date

  • June 1990

journal

  • Journal of Biological Chemistry  Journal

abstract

  • The T cell receptor (TCR) beta-chain is produced in the endoplasmic reticulum where it associates with the TCR alpha-chain and the members of the CD3 complex to form the complete receptor. When the other chains of the complex are not available, the beta-chain is rapidly degraded within the endoplasmic reticulum. When incomplete TCR.CD3 complexes are formed, they are transported through the Golgi apparatus and degraded in lysosomes. In this study, a truncated form of the TCR beta-chain has been made by removal of the transmembrane and cytoplasmic segments. Unlike the normal beta-chain, the truncated molecule is stable and is transported through the Golgi apparatus and secreted. This process occurs at a similar rate in both T and B cells, indicating that it is not affected by the presence or absence of CD3 components. These data suggest that an element in the transmembrane or cytoplasmic region of the beta-chain confers sensitivity to the degradative control mechanisms that regulate TCR expression.

subject areas

  • Acetylglucosaminidase
  • Amino Acid Sequence
  • Animals
  • Antigens, CD
  • Antigens, CD3
  • Antigens, Differentiation, T-Lymphocyte
  • B-Lymphocytes
  • Base Sequence
  • Biological Transport
  • Cloning, Molecular
  • Endoplasmic Reticulum
  • Gene Expression
  • Glycosylation
  • Golgi Apparatus
  • Immunosorbent Techniques
  • Macromolecular Substances
  • Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase
  • Mice
  • Molecular Sequence Data
  • Mutation
  • Protein Conformation
  • Protein Processing, Post-Translational
  • Receptors, Antigen, T-Cell
  • Sequence Homology, Nucleic Acid
  • T-Lymphocytes
  • Transfection
  • Tumor Cells, Cultured
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0021-9258

PubMed ID

  • 2140571
scroll to property group menus

Additional Document Info

start page

  • 9296

end page

  • 9301

volume

  • 265

issue

  • 16

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support