Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

The ATM-related cofactor Tra1 is a component of the purified SAGA complex

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Grant, P. A.
  • Schieltz, D.
  • Pray-Grant, M. G.
  • Yates III, John
  • Workman, J. L.

publication date

  • December 1998

journal

  • Molecular Cell  Journal

abstract

  • The SAGA histone acetyltransferase/transcriptional adaptor complex is composed of multiple transcriptional regulators including Ada, Spt, and TAFII proteins. Here we identify an additional novel subunit of the complex, Tra1, an ATM/PI-3-kinase-related homolog of the human TRRAP cofactor, which is essential for c-Myc and E2F-mediated oncogenic transformation. Mass spectrometry, immunoblotting, and immunoprecipitation experiments confirm the stable association of this protein within SAGA. In addition, the Tra1 protein is a component of at least two other histone acetyltransferase protein complexes. These results indicate a role for Tra1 in the regulation of transcriptional activation through the recruitment of HAT activity to an activator-bound promoter.

subject areas

  • Acetyltransferases
  • Amino Acid Sequence
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Electrophoresis, Polyacrylamide Gel
  • Fungal Proteins
  • Histone Acetyltransferases
  • Immunoblotting
  • Molecular Sequence Data
  • Multienzyme Complexes
  • Protein Kinases
  • Protein-Serine-Threonine Kinases
  • Proteins
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Tumor Suppressor Proteins
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 1097-2765

Digital Object Identifier (DOI)

  • 10.1016/s1097-2765(00)80300-7

PubMed ID

  • 9885573
scroll to property group menus

Additional Document Info

start page

  • 863

end page

  • 867

volume

  • 2

issue

  • 6

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support