Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Heparin decreases mesangial matrix accumulation after selective antibody-induced mesangial cell injury

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Tang, W. W.
  • Wilson, Curtis

publication date

  • October 1992

journal

  • Journal of the American Society of Nephrology  Journal

abstract

  • Anti-rat thymocyte antibody-induced injury of glomerular mesangial cells is characterized initially by lysis (1 h) and is followed by proliferation (beginning at 3 to 4 days), with resolution that can include a focal increase in mesangial matrix (by 28 days). Chronic administration (every 12 h) of heparin (anticoagulant or nonanticoagulant) resulted in a decrease in antibody-induced mesangial cell proliferation, which, in turn, was associated with a decrease in the size and number of areas of focal mesangial matrix increase. The effect could not be attributed to the effect of heparin on complement, to alterations in the small numbers of la-positive cells that characterize the lesion, or to binding of antibody to glomeruli. The beneficial effects of heparin in reducing mesangial cell proliferation, with a subsequent reduction in matrix increase, suggest that mesangial cell responses are a major element in the development of at least some forms of glomerulosclerosis. The possible mechanisms by which these effects of heparin may be achieved are discussed.

subject areas

  • Animals
  • Antilymphocyte Serum
  • Cell Division
  • Complement System Proteins
  • Extracellular Matrix
  • Female
  • Fluorescent Antibody Technique
  • Glomerular Mesangium
  • Heparin
  • Partial Thromboplastin Time
  • Rats
  • Rats, Inbred Lew
  • T-Lymphocytes
scroll to property group menus

Research

keywords

  • GLOMERULOSCLEROSIS
  • HEPARIN
  • MESANGIAL CELL
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 1046-6673

PubMed ID

  • 1450368
scroll to property group menus

Additional Document Info

start page

  • 921

end page

  • 929

volume

  • 3

issue

  • 4

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support