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Nucleotide-sequence of the transforming gene of m1 murine sarcoma-virus

Academic Article
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Overview

authors

  • Brow, M. A. D.
  • Sen, A.
  • Sutcliffe, J. Gregor

publication date

  • 1984

journal

  • Journal of Virology  Journal

abstract

  • The v-mosm1 nucleotide sequence codes for a protein that is 376 amino acids long. Although the N-terminus is homologous with that of the v-mos124 protein, the C-terminus is substantially different from the C-termini of all other examined mos proteins, suggesting that this region is nonessential and perhaps cleaved. Overall, v-mosm1 has greater homology with c-mos than does v-mos124, but mutually exclusive differences between c-mos and each of the v-mos genes preclude linear descent and suggest a common ancestral murine sarcoma virus.

subject areas

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Transformation, Neoplastic
  • Genes
  • Genes, Viral
  • Mice
  • Sarcoma Viruses, Murine
  • Viral Proteins
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Identity

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 6319757
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Additional Document Info

start page

  • 579

end page

  • 582

volume

  • 49

issue

  • 2

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