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Tumor necrosis factor alpha and interleukin 1 beta in synovial fluid of infants and children with suppurative arthritis

Academic Article
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Overview

authors

  • Saezllorens, X.
  • Mustafa, M. M.
  • Ramilo, O.
  • Fink, C.
  • Beutler, Bruce
  • Nelson, J. D.

publication date

  • March 1990

journal

  • American Journal of Diseases of Children  Journal

abstract

  • Tumor necrosis factor alpha and interleukin 1 beta concentrations were measured in synovial fluid of 24 infants and children with diagnoses of suppurative arthritis (n = 16) and other kinds of arthritis (n = 8). Large concentrations of tumor necrosis factor alpha (range, 100 to 85,000 pg/mL) were found in 12 (75%) of 16 patients with bacterial infection and in none of the patients with noninfectious origins. Large concentrations of interleukin 1 beta (greater than 200 pg/mL) were found in 15 (94%) of 16 patients with bacterial infection and in none of the other patients. In the latter group, small concentrations of interleukin 1 (range, 40 to 120 pg/mL) were present in 5 (63%) of 8 patients. Serum samples obtained simultaneously were negative for both cytokines. Tumor necrosis factor alpha and interleukin 1 beta concentrations correlated significantly and with leukocyte counts in synovial fluid. We conclude that large concentrations of tumor necrosis factor alpha and interleukin 1 beta are produced locally in patients with suppurative arthritis and they may be potentially useful in differentiating this condition from other kinds of arthritis.

subject areas

  • Adolescent
  • Arthritis
  • Arthritis, Infectious
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Interleukin-1
  • Male
  • Synovial Fluid
  • Tumor Necrosis Factor-alpha
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Identity

International Standard Serial Number (ISSN)

  • 0002-922X

PubMed ID

  • 2305745
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Additional Document Info

start page

  • 353

end page

  • 356

volume

  • 144

issue

  • 3

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