Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Barnett, L. A.
  • Whitton, J. Lindsay
  • Wang, L. Y.
  • Fujinami, R. S.

publication date

  • February 1996

journal

  • Journal of Neuroimmunology  Journal

abstract

  • The association of viral infections with autoimmune central nervous system (CNS) diseases such as post-infectious encephalomyelitis and possibly multiple sclerosis (MS) prompted the investigation to understand how virus infection could modulate autoimmune responses. Recombinant vaccinia viruses encoding an encephalitogenic portion of myelin basic protein (MBP) were evaluated in an animal model for human demyelinating disease, experimental allergic encephalomyelitis (EAE). We have determined that mice vaccinated with recombinant viruses encoding an encephalitogenic region of MBP were protected from EAE. In vivo depletion of CD8+ T cells did not abrogate this protection, suggesting lack of regulation by this cell type. These studies demonstrate that virus infection may be a means to modulated immune responsiveness to CNS disease.

subject areas

  • Amino Acid Sequence
  • Animals
  • Antibody Formation
  • Antigens, CD8
  • Autoimmune Diseases
  • Cells, Cultured
  • Disease Models, Animal
  • Encephalomyelitis, Autoimmune, Experimental
  • Epitopes
  • Female
  • Humans
  • Hypersensitivity, Delayed
  • Male
  • Mice
  • Mice, Inbred Strains
  • Molecular Sequence Data
  • Myelin Basic Protein
  • Peptide Fragments
  • Recombination, Genetic
  • Species Specificity
  • T-Lymphocytes
  • Vaccination
  • Vaccinia virus
scroll to property group menus

Research

keywords

  • experimental allergic encephalomyelitis
  • molecular mimicry
  • myelin basic protein
  • recombinant virus
  • vaccinia virus
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0165-5728

Digital Object Identifier (DOI)

  • 10.1016/0165-5728(95)00165-4

PubMed ID

  • 8632058
scroll to property group menus

Additional Document Info

start page

  • 163

end page

  • 173

volume

  • 64

issue

  • 2

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support