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CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies

Academic Article
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Overview

authors

  • Schwarz, H.
  • Arden, K.
  • Lotz, Martin

publication date

  • June 1997

journal

  • Biochemical and Biophysical Research Communications  Journal

abstract

  • CD137 (ILA/4-1BB) is a member of the tumor-necrosis-factor receptor family. Members of this receptor family and their structurally related ligands are important regulators of a wide variety of physiological processes and play an especially important role in the regulation of immune responses. CD137 regulates cell proliferation and survival of T-lymphocytes. Using Southern blot analysis and polymerase chain reaction, we localized the CD137 gene to chromosome 1p36. This chromosomal region harbors the genes of several other members of this receptor family and is associated with deletions and rearrangements in several malignancies.

subject areas

  • Chromosome Deletion
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1
  • Cloning, Molecular
  • Gene Rearrangement
  • Humans
  • Hybrid Cells
  • Multigene Family
  • Neoplasms
  • Polymerase Chain Reaction
  • Receptors, Tumor Necrosis Factor
  • Sequence Homology, Nucleic Acid
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1006/bbrc.1997.6870

PubMed ID

  • 9207223
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Additional Document Info

start page

  • 699

end page

  • 703

volume

  • 235

issue

  • 3

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