recent publications
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academic article
- Herman, J. D., Pepper, L. R., Cortese, J. F., Estiu, G., Galinsky, K., Zuzarte-Luis, V., Derbyshire, E. R., Ribacke, U., Lukens, A. K., Santos, S. A., Patel, V., Clish, C. B., et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs Science Translational Medicine 2015 7 DOI:10.1126/scitranslmed.aaa3575 PMID:25995223 PMCID:PMC4675670
- Fernhoff, N. B., Derbyshire, E. R., Underbakke, E. S., Marletta, M. A. Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide Journal of Biological Chemistry 2012 287:43053-43062 DOI:10.1074/jbc.M112.393892 PMID:23093402 PMCID:PMC3522300
- Gunn, A., Derbyshire, E. R., Marletta, M. A., Britt, R. D. Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR) Biochemistry 2012 51:8384-8390 DOI:10.1021/bi300831m PMID:22985445
- Derbyshire, E. R., Marletta, M. A. Structure and regulation of soluble guanylate cyclase Annual Review of Biochemistry 2012 81:533-559 DOI:10.1146/annurev-biochem-050410-100030 PMID:22404633
- Derbyshire, E. R., Winter, M. B., Ibrahim, M., Deng, S., Spiro, T. G., Marletta, M. A. Probing domain interactions in soluble guanylate cyclase Biochemistry 2011 50:4281-4290 DOI:10.1021/bi200341b PMID:21491957 PMCID:PMC3096724
- Ibrahim, M., Derbyshire, E. R., Soldatova, A. V., Marletta, M. A., Spiro, T. G. Soluble guanylate cyclase is activated differently by excess no and by yc-1: Resonance raman spectroscopic evidence Biochemistry 2010 49:4864-4871 DOI:10.1021/bi100506j PMID:20459051 PMCID:PMC2883567
- Derbyshire, E. R., Deng, S., Marletta, M. A. Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters no and o2 binding Journal of Biological Chemistry 2010 285:17471-17478 DOI:10.1074/jbc.M109.098269 PMID:20231286 PMCID:PMC2878511
- Ibrahim, M., Derbyshire, E. R., Marletta, M. A., Spiro, T. G. Probing soluble guanylate cyclase activation by co and yc-1 using resonance raman spectroscopy Biochemistry 2010 49:3815-3823 DOI:10.1021/bi902214j PMID:20353168 PMCID:PMC2894327
- Fernhoff, N. B., Derbyshire, E. R., Marletta, M. A. A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase Proceedings of the National Academy of Sciences of the United States of America 2009 106:21602-21607 DOI:10.1073/pnas.0911083106 PMID:20007374 PMCID:PMC2791033
- Derbyshire, E. R., Fernhoff, N. B., Deng, S., Marletta, M. A. Nucleotide regulation of soluble guanylate cyclase substrate specificity Biochemistry 2009 48:7519-7524 DOI:10.1021/bi900696x PMID:19527054 PMCID:PMC2742167
- Derbyshire, E. R., Marletta, M. A. Biochemistry of soluble guanylate cyclase Handbook of Experimental Pharmacology 2009 191:17-31 DOI:10.1007/978-3-540-68964-5_2 PMID:19089323
- Winger, J. A., Derbyshire, E. R., Lamers, M. H., Marletta, M. A., Kuriyan, J. The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase BMC Structural Biology 2008 8:42 DOI:10.1186/1472-6807-8-42 PMID:18842118 PMCID:PMC2576301
- Derbyshire, E. R., Gunn, A., Ibrahim, M., Spiro, T. G., Britt, R. D., Marletta, M. A. Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes Biochemistry 2008 47:3892-3899 DOI:10.1021/bi7022943 PMID:18302323 PMCID:PMC2765461
- Derbyshire, E. R., Marletta, M. A. Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase Journal of Biological Chemistry 2007 282:35741-35748 DOI:10.1074/jbc.M705557200 PMID:17916555
- Martin, N. I., Derbyshire, E. R., Marletta, M. A. Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator yc-1 Bioorganic & Medicinal Chemistry Letters 2007 17:4938-4941 DOI:10.1016/j.bmcl.2007.06.039 PMID:17587571
- Winger, J. A., Derbyshire, E. R., Marletta, M. A. Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs Journal of Biological Chemistry 2007 282:897-907 DOI:10.1074/jbc.M606327200 PMID:17098738
- Cary, S. P. L., Winger, J. A., Derbyshire, E. R., Marletta, M. A. Nitric oxide signaling: No longer simply on or off Trends in Biochemical Sciences 2006 31:231-239 DOI:10.1016/j.tibs.2006.02.003 PMID:16530415
- Derbyshire, E. R., Tran, R., Mathies, R. A., Marletta, M. A. Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase Biochemistry 2005 44:16257-16265 DOI:10.1021/bi0515671 PMID:16331986