recent publications

• academic article

  • Herman, J. D., Pepper, L. R., Cortese, J. F., Estiu, G., Galinsky, K., Zuzarte-Luis, V., Derbyshire, E. R., Ribacke, U., Lukens, A. K., Santos, S. A., Patel, V., Clish, C. B., et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs Science Translational Medicine  2015 7  DOI:10.1126/scitranslmed.aaa3575  PMID:25995223  PMCID:PMC4675670
  • Fernhoff, N. B., Derbyshire, E. R., Underbakke, E. S., Marletta, M. A. Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide Journal of Biological Chemistry  2012 287:43053-43062  DOI:10.1074/jbc.M112.393892  PMID:23093402  PMCID:PMC3522300
  • Gunn, A., Derbyshire, E. R., Marletta, M. A., Britt, R. D. Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR) Biochemistry  2012 51:8384-8390  DOI:10.1021/bi300831m  PMID:22985445
  • Derbyshire, E. R., Marletta, M. A. Structure and regulation of soluble guanylate cyclase Annual Review of Biochemistry  2012 81:533-559  DOI:10.1146/annurev-biochem-050410-100030  PMID:22404633
  • Derbyshire, E. R., Winter, M. B., Ibrahim, M., Deng, S., Spiro, T. G., Marletta, M. A. Probing domain interactions in soluble guanylate cyclase Biochemistry  2011 50:4281-4290  DOI:10.1021/bi200341b  PMID:21491957  PMCID:PMC3096724
  • Ibrahim, M., Derbyshire, E. R., Soldatova, A. V., Marletta, M. A., Spiro, T. G. Soluble guanylate cyclase is activated differently by excess no and by yc-1: Resonance raman spectroscopic evidence Biochemistry  2010 49:4864-4871  DOI:10.1021/bi100506j  PMID:20459051  PMCID:PMC2883567
  • Derbyshire, E. R., Deng, S., Marletta, M. A. Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters no and o2 binding Journal of Biological Chemistry  2010 285:17471-17478  DOI:10.1074/jbc.M109.098269  PMID:20231286  PMCID:PMC2878511
  • Ibrahim, M., Derbyshire, E. R., Marletta, M. A., Spiro, T. G. Probing soluble guanylate cyclase activation by co and yc-1 using resonance raman spectroscopy Biochemistry  2010 49:3815-3823  DOI:10.1021/bi902214j  PMID:20353168  PMCID:PMC2894327
  • Fernhoff, N. B., Derbyshire, E. R., Marletta, M. A. A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase Proceedings of the National Academy of Sciences of the United States of America  2009 106:21602-21607  DOI:10.1073/pnas.0911083106  PMID:20007374  PMCID:PMC2791033
  • Derbyshire, E. R., Fernhoff, N. B., Deng, S., Marletta, M. A. Nucleotide regulation of soluble guanylate cyclase substrate specificity Biochemistry  2009 48:7519-7524  DOI:10.1021/bi900696x  PMID:19527054  PMCID:PMC2742167
  • Derbyshire, E. R., Marletta, M. A. Biochemistry of soluble guanylate cyclase Handbook of Experimental Pharmacology  2009 191:17-31  DOI:10.1007/978-3-540-68964-5_2  PMID:19089323
  • Winger, J. A., Derbyshire, E. R., Lamers, M. H., Marletta, M. A., Kuriyan, J. The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase BMC Structural Biology  2008 8:42  DOI:10.1186/1472-6807-8-42  PMID:18842118  PMCID:PMC2576301
  • Derbyshire, E. R., Gunn, A., Ibrahim, M., Spiro, T. G., Britt, R. D., Marletta, M. A. Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes Biochemistry  2008 47:3892-3899  DOI:10.1021/bi7022943  PMID:18302323  PMCID:PMC2765461
  • Derbyshire, E. R., Marletta, M. A. Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase Journal of Biological Chemistry  2007 282:35741-35748  DOI:10.1074/jbc.M705557200  PMID:17916555
  • Martin, N. I., Derbyshire, E. R., Marletta, M. A. Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator yc-1 Bioorganic & Medicinal Chemistry Letters  2007 17:4938-4941  DOI:10.1016/j.bmcl.2007.06.039  PMID:17587571
  • Winger, J. A., Derbyshire, E. R., Marletta, M. A. Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs Journal of Biological Chemistry  2007 282:897-907  DOI:10.1074/jbc.M606327200  PMID:17098738
  • Cary, S. P. L., Winger, J. A., Derbyshire, E. R., Marletta, M. A. Nitric oxide signaling: No longer simply on or off Trends in Biochemical Sciences  2006 31:231-239  DOI:10.1016/j.tibs.2006.02.003  PMID:16530415
  • Derbyshire, E. R., Tran, R., Mathies, R. A., Marletta, M. A. Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase Biochemistry  2005 44:16257-16265  DOI:10.1021/bi0515671  PMID:16331986