recent publications

• academic article

  • Firstenberg, M. S., Dyke, C. M., Angiolillo, D. J., Ramaiahm, C., Price, M., Brtko, M., Welsby, I., Chandna, H., Holmes, D. R., Voeltz, M., Tummala, P., Hutyra, M., et al. Safety and efficacy of cangrelor, an intravenous, short-acting platelet inhibitor in patients requiring coronary artery bypass surgery Heart Surgery Forum  2013 16:E60-E69  DOI:10.1532/hsf98.20121103  PMID:23625478
  • Singh, M., White, J., Hasdai, D., Hodgson, P. K., Berger, P. B., Topol, E. J., Calif, R. M., Holmes, D. R. Long-term outcome and its predictors among patients with st-segment elevation myocardial infarction complicated by shock: Insights from the gusto-i trial Journal of the American College of Cardiology  2007 50:1752-1758  DOI:10.1016/j.jacc.2007.04.101  PMID:17964038
  • Asher, C. R., Moliterno, D. J., Bhapkar, M. V., McGuire, D. K., Rao, S. V., Holmes, D. R., Newby, L. K., Bates, E. R., Topol, E. J., Investigators, Symphony, Investigators, 2nd SYMPHONY Association of race with complications and prognosis fohowing acute coronary syndromes American Journal of Cardiology  2004 94:792-794  DOI:10.1016/j.amjcard.2004.05.069  PMID:15374792
  • Cho, L., Bhatt, D. L., Marso, S. P., Brennan, D., Holmes, D. R., Califf, R. M., Topol, E. J. An invasive strategy is associated with decreased mortality in patients with unstable angina and non-st-elevation myocardial infarction: Gusto iib trial American Journal of Medicine  2003 114:106-111  DOI:10.1016/s0002-9343(02)01446-8  PMID:12586229
  • Hasdai, D., Topol, E. J., Kilaru, R., Battler, A., Harrington, R. A., Vahanian, A., Ohman, E. M., Granger, C. B., Van de Werf, F., Simoons, M. L., O'Connor, C. M., Holmes, D. R. Frequency, patient characteristics, and, outcomes of mild-to-moderate heart failure complicating st-segment elevation acute myocardial infarction: Lessons from 4 international fibrinolytic therapy trials American Heart Journal  2003 145:73-79  DOI:10.1067/mhj.2003.53  PMID:12514657
  • Grines, C., Patel, A., Zijlstra, F., Weaver, W. D., Granger, C., Simes, R. J., Ellis, S., Betriu, A., Garcia, E., Grinfeld, L., Gibbons, R., Ribeiro, E., et al. Primary coronary angioplasty compared with intravenous thrombolytic therapy for acute myocardial infarction: Six-month follow up and analysis of individual patient data from randomized trials American Heart Journal  2003 145:47-57  DOI:10.1067/mhj.2003.40  PMID:12514654
  • Bhatt, D. L., Bertrand, M. E., Berger, P. B., L'Allier, P. L., Moussa, I., Moses, J. W., Dangas, G., Taniuchi, M., Lasala, J. M., Holmes, D. R., Ellis, S. G., Topol, E. J. Meta-analysis of randomized and registry comparisons of ticlopidine with clopidogrel after stenting Journal of the American College of Cardiology  2002 39:9-14  DOI:10.1016/s0735-1097(01)01713-2  PMID:11755280
  • Labinaz, M., Sketch, M. H., Ellis, S. G., Abramowitz, B. M., Stebbins, A. L., Pieper, K. S., Holmes, D. R., Califf, R. M., Topol, E. J. Outcome of acute st-segment elevation myocardial infarction in patients with prior coronary artery bypass surgery receiving thrombolytic therapy American Heart Journal  2001 141:469-477  DOI:10.1067/mhj.2001.112779  PMID:11231447
  • Hasdai, D., Holmes, D. R., Criger, D. A., Topol, E. J., Califf, R. M., Harrington, R. A., Pursuit Trial ,Investigators Age and outcome after acute coronary syndromes without persistent st-segment elevation American Heart Journal  2000 139:858-866  DOI:10.1016/s0002-8703(00)90018-8  PMID:10783220
  • Bruce, C. J., Kuntz, R. E., Popma, J. J., Pieper, K. S., Topol, E. J., Holmes, D. R. Application of a continuous regression model of restenosis to saphenous vein grafts after successful percutaneous transluminal coronary angioplasty or directional coronary atherectomy Journal of the American College of Cardiology  2000 35:619-623  DOI:10.1016/s0735-1097(99)00595-1  PMID:10716463
  • Hasdai, D., Topol, E. J., Califf, R. M., Berger, P. B., Holmes, D. R. Cardiogenic shock complicating acute coronary syndromes Lancet  2000 356:749-756  DOI:10.1016/s0140-6736(00)02640-4  PMID:11085707
  • Hasdai, D., Holmes, D. R., Criger, D. A., Topol, E. J., Califf, R. M., Wilcox, R. G., Paolasso, E., Simoons, M., Deckers, J., Harrington, R. A., investigators, Pursuit trial Cigarette smoking status and outcome among patients with acute coronary syndromes without persistent st-segment elevation: Effect of inhibition of platelet glycoprotein iib/iiia with eptifibatide American Heart Journal  2000 139:454-460  DOI:10.1067/mhj.2000.103847  PMID:10689260
  • Topol, C. E., Califf, R. M., Simes, R. J., Van de Werf, F., Diaz, R., Paolasso, E., Aylward, P. E., Keech, A., Klein, W., Piegas, L., Tomov, I., Armstrong, P. W., et al. Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: A randomised trial Lancet  2000 355:337-345  PMID:10665552
  • Hasdai, D., Granger, C. B., Srivatsa, S. S., Criger, D. A., Ellis, S. G., Califf, R. M., Topol, E. J., Holmes, D. R. Diabetes mellitus and outcome after primary coronary angioplasty for acute myocardial infarction: Lessons from the gusto-iib angioplasty substudy Journal of the American College of Cardiology  2000 35:1502-1512  DOI:10.1016/s0735-1097(00)00591-x  PMID:10807453
  • Menon, V., Hochman, J. S., Stebbins, A., Pfisterer, M., Col, J., Anderson, R. D., Hasdai, D., Holmes, D. R., Bates, E. R., Topol, E. J., Califf, R. M., Ohman, E. M., et al. Lack of progress in cardiogenic shock: Lessons from the gusto trials European Heart Journal  2000 21:1928-1936  DOI:10.1053/euhj.2000.2240  PMID:11071798
  • Hasdai, D., Harrington, R. A., Hochman, J. S., Califf, R. M., Battler, A., Box, J. W., Simoons, M. L., Deckers, J., Topol, E. J., Holmes, D. R. Platelet glycoprotein iib/iiia blockade and outcome of cardiogenic shock complicating acute coronary syndromes without persistent st-segment elevation Journal of the American College of Cardiology  2000 36:685-692  DOI:10.1016/s0735-1097(00)00814-7  PMID:10987585
  • Hasdai, D., Califf, R. M., Thompson, T. D., Hochman, J. S., Ohman, E. M., Pfisterer, M., Bates, E. R., Vahanian, A., Armstrong, P. W., Criger, D. A., Topol, E. J., Holmes, D. R. Predictors of cardiogenic shock after thrombolytic therapy for acute myocardial infarction Journal of the American College of Cardiology  2000 35:136-143  DOI:10.1016/s0735-1097(99)00508-2  PMID:10636271
  • Hasdai, D., Holmes, D. R., Califf, R. M., Thompson, T. D., Hochman, J. S., Pfisterer, M., Topol, E. J., Investigators, Gusto- I. Acute ischemic heart disease - cardiogenic shock complicating acute myocardial infarction: Predictors of death American Heart Journal  1999 138:21-31  DOI:10.1016/s0002-8703(99)70241-3  PMID:10385759
  • Holmes, D. R., Barger, P. B., Hochman, J. S., Granger, C. B., Thompson, T. D., Califf, R. M., Vahanian, A., Bates, E. R., Topol, E. J. Cardiogenic shock in patients with acute ischemic syndromes with and without st-segment elevation Circulation  1999 100:2067-2073  PMID:10562262
  • Holmes, D. R., White, H. D., Pieper, K. S., Ellis, S. G., Califf, R. M., Topol, E. J. Effect of age on outcome with primary angioplasty versus thrombolysis Journal of the American College of Cardiology  1999 33:412-419  DOI:10.1016/s0735-1097(98)00579-8  PMID:9973021
  • Hasdai, D., Holmes, D. R., Topol, E. J., Berger, P. B., Criger, D. A., Hochman, J. S., Bates, E. R., Vahanian, A., Armstrong, P. W., Wilcox, R., Ohman, E. M., Califf, R. M. Frequency and clinical outcome of cardiogenic shock during acute myocardial infarction among patients receiving reteplase or alteplase - results from gusto-iii European Heart Journal  1999 20:128-135  DOI:10.1053/euhj.1999.1282  PMID:10099909
  • Harrington, R. A., Califf, R. M., Holmes, D. R., Pieper, K. S., Lincoff, A. M., Berdan, L. G., Thompson, T. D., Topol, E. J., Investigators, Caveat- I. Is all unstable angina the same? Insights from the coronary angioplasty versus excisional atherectamy trial (caveat-i) American Heart Journal  1999 137:227-233  DOI:10.1053/hj.1999.v137.90600  PMID:9924155
  • Berger, P. B., Tuttle, R. H., Holmes, D. R., Topol, E. J., Aylward, P. E., Horgan, J. H., Califf, R. M., Investigators, Gusto I. One-year survival among patients with acute myocardial infarction complicated by cardiogenic shock, and its relation to early revascularization - results from the gusto-i trial Circulation  1999 99:873-878  PMID:10027808
  • Berger, P. B., Ellis, S. G., Holmes, D. R., Granger, C. B., Criger, D. A., Betriu, A., Topol, E. J., Califf, R. M., Investigators, Gusto Ii Relationship between delay in performing direct coronary angioplasty and early clinical outcome in patients with acute myocardial infarction - results from the global use of strategies to open occluded arteries in acute coronary syndromes (gusto-iib) trial Circulation  1999 100:14-20  PMID:10393675
  • Hasdai, D., Lerman, A., Rihal, C. S., Criger, D. A., Garratt, K. N., Betriu, A., White, H. D., Topol, E. J., Granger, C. B., Ellis, S. G., Califf, R. M., Holmes, D. R. Smoking status and outcome after primary coronary angioplasty for acute myocardial infarction American Heart Journal  1999 137:612-620  DOI:10.1016/s0002-8703(99)70213-9  PMID:10097222
  • Anderson, R. D., Ohman, E. M., Holmes, D. R., Harrington, R. A., Barsness, G. W., Wildermann, N. M., Phillips, H. R., Topol, E. J., Califf, R. M. Prognostic value of congestive heart failure history in patients undergoing percutaneous coronary interventions Journal of the American College of Cardiology  1998 32:936-941  DOI:10.1016/s0735-1097(98)00339-8  PMID:9768714
  • Forrester, J. S., Topol, E. J., Abele, J. E., Holmes, D. R., Skorton, D. J. 28th Bethesda Conference. Task force 5: Assessment, approval, and regulation of new technology Journal of the American College of Cardiology  1997 29:1171-1179  PMID:9137210
  • Holmes, D. R., Califf, R. M., VandeWerf, F., Berger, P. B., Bates, E. R., Simoons, M. L., White, H. D., Thompson, T. D., Topol, E. J. Difference in countries' use of resources and clinical outcome for patients with cardiogenic shock after myocardial infarction: Results from the gusto trial Lancet  1997 349:75-78  DOI:10.1016/s0140-6736(96)03031-0  PMID:8996417
  • Berger, P. B., Holmes, D. R., Stebbins, A. L., Bates, E. R., Califf, R. M., Topol, E. J. Impact of an aggressive invasive catheterization and revascularization strategy on mortality in patients with cardiogenic shock in the global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries (gusto-i) trial - an observational study Circulation  1997 96:122-127  PMID:9236426
  • Anderson, R. D., Ohman, E. M., Holmes, D. R., Col, J., Stebbins, A. L., Bates, E. R., Stomel, R. J., Granger, C. B., Topol, E. J., Califf, R. M. Use of intraaortic balloon counterpulsation in patients presenting with cardiogenic shock: Observations from the gusto-i study Journal of the American College of Cardiology  1997 30:708-715  DOI:10.1016/s0735-1097(97)00227-1  PMID:9283530
  • Pepine, C. J., Holmes, D. R., Block, P. C., Brinker, J. A., Mark, D. B., Mullins, C. E., Nissen, S. E., Topol, E. J., Williams, D. O., Goldberg, S., Hirshfeld, J. W., Serruys, P. W. Coronary artery stents Journal of the American College of Cardiology  1996 28:782-794  PMID:8772772
  • Holmes, D. R., Garratt, K. N., Isner, J. M., Kearney, M., Berdan, L. G., Schwartz, R. S., Califf, R. M., Topol, E. J. Effect of subintimal resection on initial outcome and restenosis for native coronary lesions and saphenous vein graft disease treated by directional coronary atherectomy - a report from the caveat i and ii investigators Journal of the American College of Cardiology  1996 28:645-651  DOI:10.1016/0735-1097(96)00185-4  PMID:8772751
  • vanderGiessen, W. J., Lincoff, A. M., Schwartz, R. S., vanBeusekom, H. M. M., Serruys, P. W., Holmes, D. R., Ellis, S. G., Topol, E. J. Marked inflammatory sequelae to implantation of biodegradable and nonbiodegradable polymers in porcine coronary arteries Circulation  1996 94:1690-1697  PMID:8840862
  • Labinaz, M., Sketch, M. H., Stebbins, A. L., DeFranco, A. C., Holmes, D. R., Kleiman, N. S., Betriu, A., Rutsch, W. R., Vahanian, A., Topol, E. J., Califf, R. M. Thrombolytic therapy for patients with prior percutaneous transluminal coronary angioplasty and subsequent acute myocardial infarction American Journal of Cardiology  1996 78:1338-1344  DOI:10.1016/s0002-9149(96)00654-6  PMID:8970403
  • Pichard, A., Ivanhoe, R., Satler, L., Masden, R., Chapekis, A., Lee, K. L., Reen, B., Levine, G., Abbottsmith, C., Gottlieb, R. S., Stillabower, M., Chambers, J., et al. A multicenter, randomized trial of coronary angioplasty versus directional atherectomy for patients with saphenous vein bypass graft lesions Circulation  1995 91:1966-1974  PMID:7895354
  • Holmes, D. R., Simpson, J. B., Berdan, L. G., Gottlieb, R. S., Leya, F., Keeler, G. P., Califf, R. M., Topol, E. J. Abrupt closure - the caveat-i experience Journal of the American College of Cardiology  1995 26:1494-1500  DOI:10.1016/0735-1097(95)00339-8  PMID:7594076
  • Harrington, R. A., Lincoff, A. M., Califf, R. M., Holmes, D. R., Berdan, L. G., Ohanesian, M. A., Keeler, G. P., Garratt, K. N., Ohman, E. M., Mark, D. B., Jacobs, A. K., Topol, E. J. Characteristics and consequences of myocardial-infarction after percutaneous coronary intervention - insights from the coronary angioplasty versus excisional atherectomy trial (caveat) Journal of the American College of Cardiology  1995 25:1693-1699  DOI:10.1016/0735-1097(95)00091-h  PMID:7759725
  • Holmes, D. R., Bates, E. R., Kleiman, N. S., Sadowski, Z., Horgan, J. H. S., Morris, D. C., Califf, R. M., Berger, P. B., Topol, E. J. Contemporary reperfusion therapy for cardiogenic-shock - the gusto-i trial experience Journal of the American College of Cardiology  1995 26:668-674  DOI:10.1016/0735-1097(95)00215-p  PMID:7642857
  • Boehrer, J. D., Ellis, S. G., Pieper, K., Holmes, D. R., Keeler, G. P., Debowey, D., Chapekis, A. T., Leya, F., Mooney, M. R., Gottlieb, R. S., Serruys, P. W., Califf, R. M., et al. Directional atherectomy versus balloon angioplasty for coronary ostial and nonostial left anterior descending coronary-artery lesions - results from a randomized multicenter trial Journal of the American College of Cardiology  1995 25:1380-1386  DOI:10.1016/0735-1097(95)00008-r  PMID:7722137
  • Holmes, D. R., Califf, R. M., Topol, E. J. Lessons we have learned from the gusto trial Journal of the American College of Cardiology  1995 25:S10-S17  DOI:10.1016/0735-1097(95)90011-x
  • Simes, R. J., Topol, E. J., Holmes, D. R., White, H. D., Rutsch, W. R., Vahanian, A., Simoons, M. L., Morris, D., Betriu, A., Califf, R. M., Ross, A. M. Link between the angiographic substudy and mortality outcomes in a large randomized trial of myocardial reperfusion - importance of early and complete infarct artery reperfusion Circulation  1995 91:1923-1928  PMID:7895348
  • Elliott, J. M., Berdan, L. G., Holmes, D. R., Isner, J. M., King, S. B., Keeler, G. P., Kearney, M., Califf, R. M., Topol, E. J. One-year follow-up in the coronary angioplasty versus excisional atherectomy trial (caveat-i) Circulation  1995 91:2158-2166  PMID:7697844
  • Lefkovits, J., Holmes, D. R., Califf, R. M., Safian, R. D., Pieper, K., Keeler, G., Topol, E. J. Predictors and sequelae of distal embolization during saphenous-vein graft intervention from the caveat-ii trial Circulation  1995 92:734-740  PMID:7641351
  • Nissen, S. E., Pepine, C. J., Bashore, T. M., Block, P. C., Bonchek, L. I., Brinker, J. A., Carabello, B., Douglas, J. S., Elion, J. L., Hirshfeld, J. W., Holmes, D. R., Johnson, W. L., et al. Cardiac angiography without cine film - erecting a tower-of-babel in the cardiac-catheterization laboratory Journal of the American College of Cardiology  1994 24:834-837  PMID:8077561
  • Holmes, D. R., Topol, E. J. Dilate or debulk Cleveland Clinic Journal of Medicine  1994 61:124-126  PMID:8194176
  • Sutton, J. M., Ellis, S. G., Roubin, G. S., Pinkerton, C. A., King, S. B., Raizner, A. E., Holmes, D. R., Kereiakes, D. J., Topol, E. J. Major clinical events after coronary stenting - the multicenter registry of acute and elective gianturco-roubin stent placement Circulation  1994 89:1126-1137  PMID:8124799
  • Kleiman, N. S., White, H. D., Ohman, E. M., Ross, A. M., Woodlief, L. H., Califf, R. M., Holmes, D. R., Bates, E., Pfisterer, M., Vahanian, A., Topol, E. J. Mortality within 24 hours of thrombolysis for myocardial-infarction - the importance of early reperfusion Circulation  1994 90:2658-2665  PMID:7994805
  • Holmes, D. R., Topol, E. J., Adelman, A. G., Cohen, E. A., Califf, R. M. Randomized trials of directional coronary atherectomy - implications for clinical-practice and future investigation Journal of the American College of Cardiology  1994 24:431-439  PMID:8034880
  • Topol, E. J., Leya, F., Pinkerton, C. A., Whitlow, P. L., Hofling, B., Simonton, C. A., Masden, R. R., Serruys, P. W., Leon, M. B., Williams, D. O., King, S. B., Mark, D. B., et al. A comparison of directional atherectomy with coronary angioplasty in patients with coronary-artery disease New England Journal of Medicine  1993 329:221-227  DOI:10.1056/nejm199307223290401  PMID:8316266
  • George, B. S., Voorhees, W. D., Roubin, G. S., Fearnot, N. E., Pinkerton, C. A., Raizner, A. E., King, S. B., Holmes, D. R., Topol, E. J., Kereiakes, D. J., Hartzler, G. O. Multicenter investigation of coronary stenting to treat acute or threatened closure after percutaneous transluminal coronary angioplasty - clinical and angiographic outcomes Journal of the American College of Cardiology  1993 22:135-143  PMID:8509533
  • Popma, J. J., Decesare, N. B., Pinkerton, C. A., Kereiakes, D. J., Whitlow, P., King, S. B., Topol, E. J., Holmes, D. R., Leon, M. B., Ellis, S. G. Quantitative-analysis of factors influencing late lumen loss and restenosis after directional coronary atherectomy American Journal of Cardiology  1993 71:552-557  DOI:10.1016/0002-9149(93)90510-j  PMID:8438740
  • Popma, J. J., Topol, E. J., Hinohara, T., Pinkerton, C. A., Baim, D. S., King, S. B., Holmes, D. R., Whitlow, P. L., Kereiakes, D. J., Hartzler, G. O., Kent, K. M., Ellis, S. G., et al. Abrupt vessel closure after directional coronary atherectomy Journal of the American College of Cardiology  1992 19:1372-1379  PMID:1593028
  • Decesare, N. B., Popma, J. J., Holmes, D. R., Dick, R. J., Whitlow, P. L., King, S. B., Pinkerton, C. A., Kereiakes, D. J., Topol, E. J., Haudenschild, C. C., Ellis, S. G. Clinical angiographic and histologic correlates of ectasia after directional coronary atherectomy American Journal of Cardiology  1992 69:314-319  DOI:10.1016/0002-9149(92)90226-o  PMID:1734641
  • Schwartz, R. S., Holmes, D. R., Topol, E. J. The restenosis paradigm revisited - an alternative proposal for cellular mechanisms Journal of the American College of Cardiology  1992 20:1284-1293  PMID:1401633
  • Popma, J. J., Decesare, N. B., Ellis, S. G., Holmes, D. R., Pinkerton, C. A., Whitlow, P., King, S. B., Ghazzal, Z. M. B., Topol, E. J., Garratt, K. N., Kereiakes, D. J. Clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy Journal of the American College of Cardiology  1991 18:1183-1189  PMID:1918694
  • Topol, E. J., Holmes, D. R., Rogers, W. J. Coronary angiography after thrombolytic therapy for acute myocardial-infarction Annals of Internal Medicine  1991 114:877-885  PMID:2014950
  • Ellis, S. G., Decesare, N. B., Pinkerton, C. A., Whitlow, P., King, S. B., Ghazzal, Z. M. B., Kereiakes, D. J., Popma, J. J., Menke, K. K., Topol, E. J., Holmes, D. R. Relation of stenosis morphology and clinical presentation to the procedural results of directional coronary atherectomy Circulation  1991 84:644-653  PMID:1860208
  • Holmes, D. R., Topol, E. J. Reperfusion momentum - lessons from the randomized trials of immediate coronary angioplasty for myocardial-infarction Journal of the American College of Cardiology  1989 14:1572-1578  DOI:10.1016/0735-1097(89)90401-4  PMID:2809019