recent publications
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academic article
- Firstenberg, M. S., Dyke, C. M., Angiolillo, D. J., Ramaiahm, C., Price, M., Brtko, M., Welsby, I., Chandna, H., Holmes, D. R., Voeltz, M., Tummala, P., Hutyra, M., et al. Safety and efficacy of cangrelor, an intravenous, short-acting platelet inhibitor in patients requiring coronary artery bypass surgery Heart Surgery Forum 2013 16:E60-E69 DOI:10.1532/hsf98.20121103 PMID:23625478
- Singh, M., White, J., Hasdai, D., Hodgson, P. K., Berger, P. B., Topol, E. J., Calif, R. M., Holmes, D. R. Long-term outcome and its predictors among patients with st-segment elevation myocardial infarction complicated by shock: Insights from the gusto-i trial Journal of the American College of Cardiology 2007 50:1752-1758 DOI:10.1016/j.jacc.2007.04.101 PMID:17964038
- Asher, C. R., Moliterno, D. J., Bhapkar, M. V., McGuire, D. K., Rao, S. V., Holmes, D. R., Newby, L. K., Bates, E. R., Topol, E. J., Investigators, Symphony, Investigators, 2nd SYMPHONY Association of race with complications and prognosis fohowing acute coronary syndromes American Journal of Cardiology 2004 94:792-794 DOI:10.1016/j.amjcard.2004.05.069 PMID:15374792
- Cho, L., Bhatt, D. L., Marso, S. P., Brennan, D., Holmes, D. R., Califf, R. M., Topol, E. J. An invasive strategy is associated with decreased mortality in patients with unstable angina and non-st-elevation myocardial infarction: Gusto iib trial American Journal of Medicine 2003 114:106-111 DOI:10.1016/s0002-9343(02)01446-8 PMID:12586229
- Hasdai, D., Topol, E. J., Kilaru, R., Battler, A., Harrington, R. A., Vahanian, A., Ohman, E. M., Granger, C. B., Van de Werf, F., Simoons, M. L., O'Connor, C. M., Holmes, D. R. Frequency, patient characteristics, and, outcomes of mild-to-moderate heart failure complicating st-segment elevation acute myocardial infarction: Lessons from 4 international fibrinolytic therapy trials American Heart Journal 2003 145:73-79 DOI:10.1067/mhj.2003.53 PMID:12514657
- Grines, C., Patel, A., Zijlstra, F., Weaver, W. D., Granger, C., Simes, R. J., Ellis, S., Betriu, A., Garcia, E., Grinfeld, L., Gibbons, R., Ribeiro, E., et al. Primary coronary angioplasty compared with intravenous thrombolytic therapy for acute myocardial infarction: Six-month follow up and analysis of individual patient data from randomized trials American Heart Journal 2003 145:47-57 DOI:10.1067/mhj.2003.40 PMID:12514654
- Bhatt, D. L., Bertrand, M. E., Berger, P. B., L'Allier, P. L., Moussa, I., Moses, J. W., Dangas, G., Taniuchi, M., Lasala, J. M., Holmes, D. R., Ellis, S. G., Topol, E. J. Meta-analysis of randomized and registry comparisons of ticlopidine with clopidogrel after stenting Journal of the American College of Cardiology 2002 39:9-14 DOI:10.1016/s0735-1097(01)01713-2 PMID:11755280
- Labinaz, M., Sketch, M. H., Ellis, S. G., Abramowitz, B. M., Stebbins, A. L., Pieper, K. S., Holmes, D. R., Califf, R. M., Topol, E. J. Outcome of acute st-segment elevation myocardial infarction in patients with prior coronary artery bypass surgery receiving thrombolytic therapy American Heart Journal 2001 141:469-477 DOI:10.1067/mhj.2001.112779 PMID:11231447
- Hasdai, D., Holmes, D. R., Criger, D. A., Topol, E. J., Califf, R. M., Harrington, R. A., Pursuit Trial ,Investigators Age and outcome after acute coronary syndromes without persistent st-segment elevation American Heart Journal 2000 139:858-866 DOI:10.1016/s0002-8703(00)90018-8 PMID:10783220
- Bruce, C. J., Kuntz, R. E., Popma, J. J., Pieper, K. S., Topol, E. J., Holmes, D. R. Application of a continuous regression model of restenosis to saphenous vein grafts after successful percutaneous transluminal coronary angioplasty or directional coronary atherectomy Journal of the American College of Cardiology 2000 35:619-623 DOI:10.1016/s0735-1097(99)00595-1 PMID:10716463
- Hasdai, D., Topol, E. J., Califf, R. M., Berger, P. B., Holmes, D. R. Cardiogenic shock complicating acute coronary syndromes Lancet 2000 356:749-756 DOI:10.1016/s0140-6736(00)02640-4 PMID:11085707
- Hasdai, D., Holmes, D. R., Criger, D. A., Topol, E. J., Califf, R. M., Wilcox, R. G., Paolasso, E., Simoons, M., Deckers, J., Harrington, R. A., investigators, Pursuit trial Cigarette smoking status and outcome among patients with acute coronary syndromes without persistent st-segment elevation: Effect of inhibition of platelet glycoprotein iib/iiia with eptifibatide American Heart Journal 2000 139:454-460 DOI:10.1067/mhj.2000.103847 PMID:10689260
- Topol, C. E., Califf, R. M., Simes, R. J., Van de Werf, F., Diaz, R., Paolasso, E., Aylward, P. E., Keech, A., Klein, W., Piegas, L., Tomov, I., Armstrong, P. W., et al. Comparison of sibrafiban with aspirin for prevention of cardiovascular events after acute coronary syndromes: A randomised trial Lancet 2000 355:337-345 PMID:10665552
- Hasdai, D., Granger, C. B., Srivatsa, S. S., Criger, D. A., Ellis, S. G., Califf, R. M., Topol, E. J., Holmes, D. R. Diabetes mellitus and outcome after primary coronary angioplasty for acute myocardial infarction: Lessons from the gusto-iib angioplasty substudy Journal of the American College of Cardiology 2000 35:1502-1512 DOI:10.1016/s0735-1097(00)00591-x PMID:10807453
- Menon, V., Hochman, J. S., Stebbins, A., Pfisterer, M., Col, J., Anderson, R. D., Hasdai, D., Holmes, D. R., Bates, E. R., Topol, E. J., Califf, R. M., Ohman, E. M., et al. Lack of progress in cardiogenic shock: Lessons from the gusto trials European Heart Journal 2000 21:1928-1936 DOI:10.1053/euhj.2000.2240 PMID:11071798
- Hasdai, D., Harrington, R. A., Hochman, J. S., Califf, R. M., Battler, A., Box, J. W., Simoons, M. L., Deckers, J., Topol, E. J., Holmes, D. R. Platelet glycoprotein iib/iiia blockade and outcome of cardiogenic shock complicating acute coronary syndromes without persistent st-segment elevation Journal of the American College of Cardiology 2000 36:685-692 DOI:10.1016/s0735-1097(00)00814-7 PMID:10987585
- Hasdai, D., Califf, R. M., Thompson, T. D., Hochman, J. S., Ohman, E. M., Pfisterer, M., Bates, E. R., Vahanian, A., Armstrong, P. W., Criger, D. A., Topol, E. J., Holmes, D. R. Predictors of cardiogenic shock after thrombolytic therapy for acute myocardial infarction Journal of the American College of Cardiology 2000 35:136-143 DOI:10.1016/s0735-1097(99)00508-2 PMID:10636271
- Hasdai, D., Holmes, D. R., Califf, R. M., Thompson, T. D., Hochman, J. S., Pfisterer, M., Topol, E. J., Investigators, Gusto- I. Acute ischemic heart disease - cardiogenic shock complicating acute myocardial infarction: Predictors of death American Heart Journal 1999 138:21-31 DOI:10.1016/s0002-8703(99)70241-3 PMID:10385759
- Holmes, D. R., Barger, P. B., Hochman, J. S., Granger, C. B., Thompson, T. D., Califf, R. M., Vahanian, A., Bates, E. R., Topol, E. J. Cardiogenic shock in patients with acute ischemic syndromes with and without st-segment elevation Circulation 1999 100:2067-2073 PMID:10562262
- Holmes, D. R., White, H. D., Pieper, K. S., Ellis, S. G., Califf, R. M., Topol, E. J. Effect of age on outcome with primary angioplasty versus thrombolysis Journal of the American College of Cardiology 1999 33:412-419 DOI:10.1016/s0735-1097(98)00579-8 PMID:9973021
- Hasdai, D., Holmes, D. R., Topol, E. J., Berger, P. B., Criger, D. A., Hochman, J. S., Bates, E. R., Vahanian, A., Armstrong, P. W., Wilcox, R., Ohman, E. M., Califf, R. M. Frequency and clinical outcome of cardiogenic shock during acute myocardial infarction among patients receiving reteplase or alteplase - results from gusto-iii European Heart Journal 1999 20:128-135 DOI:10.1053/euhj.1999.1282 PMID:10099909
- Harrington, R. A., Califf, R. M., Holmes, D. R., Pieper, K. S., Lincoff, A. M., Berdan, L. G., Thompson, T. D., Topol, E. J., Investigators, Caveat- I. Is all unstable angina the same? Insights from the coronary angioplasty versus excisional atherectamy trial (caveat-i) American Heart Journal 1999 137:227-233 DOI:10.1053/hj.1999.v137.90600 PMID:9924155
- Berger, P. B., Tuttle, R. H., Holmes, D. R., Topol, E. J., Aylward, P. E., Horgan, J. H., Califf, R. M., Investigators, Gusto I. One-year survival among patients with acute myocardial infarction complicated by cardiogenic shock, and its relation to early revascularization - results from the gusto-i trial Circulation 1999 99:873-878 PMID:10027808
- Berger, P. B., Ellis, S. G., Holmes, D. R., Granger, C. B., Criger, D. A., Betriu, A., Topol, E. J., Califf, R. M., Investigators, Gusto Ii Relationship between delay in performing direct coronary angioplasty and early clinical outcome in patients with acute myocardial infarction - results from the global use of strategies to open occluded arteries in acute coronary syndromes (gusto-iib) trial Circulation 1999 100:14-20 PMID:10393675
- Hasdai, D., Lerman, A., Rihal, C. S., Criger, D. A., Garratt, K. N., Betriu, A., White, H. D., Topol, E. J., Granger, C. B., Ellis, S. G., Califf, R. M., Holmes, D. R. Smoking status and outcome after primary coronary angioplasty for acute myocardial infarction American Heart Journal 1999 137:612-620 DOI:10.1016/s0002-8703(99)70213-9 PMID:10097222
- Anderson, R. D., Ohman, E. M., Holmes, D. R., Harrington, R. A., Barsness, G. W., Wildermann, N. M., Phillips, H. R., Topol, E. J., Califf, R. M. Prognostic value of congestive heart failure history in patients undergoing percutaneous coronary interventions Journal of the American College of Cardiology 1998 32:936-941 DOI:10.1016/s0735-1097(98)00339-8 PMID:9768714
- Forrester, J. S., Topol, E. J., Abele, J. E., Holmes, D. R., Skorton, D. J. 28th Bethesda Conference. Task force 5: Assessment, approval, and regulation of new technology Journal of the American College of Cardiology 1997 29:1171-1179 PMID:9137210
- Holmes, D. R., Califf, R. M., VandeWerf, F., Berger, P. B., Bates, E. R., Simoons, M. L., White, H. D., Thompson, T. D., Topol, E. J. Difference in countries' use of resources and clinical outcome for patients with cardiogenic shock after myocardial infarction: Results from the gusto trial Lancet 1997 349:75-78 DOI:10.1016/s0140-6736(96)03031-0 PMID:8996417
- Berger, P. B., Holmes, D. R., Stebbins, A. L., Bates, E. R., Califf, R. M., Topol, E. J. Impact of an aggressive invasive catheterization and revascularization strategy on mortality in patients with cardiogenic shock in the global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries (gusto-i) trial - an observational study Circulation 1997 96:122-127 PMID:9236426
- Anderson, R. D., Ohman, E. M., Holmes, D. R., Col, J., Stebbins, A. L., Bates, E. R., Stomel, R. J., Granger, C. B., Topol, E. J., Califf, R. M. Use of intraaortic balloon counterpulsation in patients presenting with cardiogenic shock: Observations from the gusto-i study Journal of the American College of Cardiology 1997 30:708-715 DOI:10.1016/s0735-1097(97)00227-1 PMID:9283530
- Pepine, C. J., Holmes, D. R., Block, P. C., Brinker, J. A., Mark, D. B., Mullins, C. E., Nissen, S. E., Topol, E. J., Williams, D. O., Goldberg, S., Hirshfeld, J. W., Serruys, P. W. Coronary artery stents Journal of the American College of Cardiology 1996 28:782-794 PMID:8772772
- Holmes, D. R., Garratt, K. N., Isner, J. M., Kearney, M., Berdan, L. G., Schwartz, R. S., Califf, R. M., Topol, E. J. Effect of subintimal resection on initial outcome and restenosis for native coronary lesions and saphenous vein graft disease treated by directional coronary atherectomy - a report from the caveat i and ii investigators Journal of the American College of Cardiology 1996 28:645-651 DOI:10.1016/0735-1097(96)00185-4 PMID:8772751
- vanderGiessen, W. J., Lincoff, A. M., Schwartz, R. S., vanBeusekom, H. M. M., Serruys, P. W., Holmes, D. R., Ellis, S. G., Topol, E. J. Marked inflammatory sequelae to implantation of biodegradable and nonbiodegradable polymers in porcine coronary arteries Circulation 1996 94:1690-1697 PMID:8840862
- Labinaz, M., Sketch, M. H., Stebbins, A. L., DeFranco, A. C., Holmes, D. R., Kleiman, N. S., Betriu, A., Rutsch, W. R., Vahanian, A., Topol, E. J., Califf, R. M. Thrombolytic therapy for patients with prior percutaneous transluminal coronary angioplasty and subsequent acute myocardial infarction American Journal of Cardiology 1996 78:1338-1344 DOI:10.1016/s0002-9149(96)00654-6 PMID:8970403
- Pichard, A., Ivanhoe, R., Satler, L., Masden, R., Chapekis, A., Lee, K. L., Reen, B., Levine, G., Abbottsmith, C., Gottlieb, R. S., Stillabower, M., Chambers, J., et al. A multicenter, randomized trial of coronary angioplasty versus directional atherectomy for patients with saphenous vein bypass graft lesions Circulation 1995 91:1966-1974 PMID:7895354
- Holmes, D. R., Simpson, J. B., Berdan, L. G., Gottlieb, R. S., Leya, F., Keeler, G. P., Califf, R. M., Topol, E. J. Abrupt closure - the caveat-i experience Journal of the American College of Cardiology 1995 26:1494-1500 DOI:10.1016/0735-1097(95)00339-8 PMID:7594076
- Harrington, R. A., Lincoff, A. M., Califf, R. M., Holmes, D. R., Berdan, L. G., Ohanesian, M. A., Keeler, G. P., Garratt, K. N., Ohman, E. M., Mark, D. B., Jacobs, A. K., Topol, E. J. Characteristics and consequences of myocardial-infarction after percutaneous coronary intervention - insights from the coronary angioplasty versus excisional atherectomy trial (caveat) Journal of the American College of Cardiology 1995 25:1693-1699 DOI:10.1016/0735-1097(95)00091-h PMID:7759725
- Holmes, D. R., Bates, E. R., Kleiman, N. S., Sadowski, Z., Horgan, J. H. S., Morris, D. C., Califf, R. M., Berger, P. B., Topol, E. J. Contemporary reperfusion therapy for cardiogenic-shock - the gusto-i trial experience Journal of the American College of Cardiology 1995 26:668-674 DOI:10.1016/0735-1097(95)00215-p PMID:7642857
- Boehrer, J. D., Ellis, S. G., Pieper, K., Holmes, D. R., Keeler, G. P., Debowey, D., Chapekis, A. T., Leya, F., Mooney, M. R., Gottlieb, R. S., Serruys, P. W., Califf, R. M., et al. Directional atherectomy versus balloon angioplasty for coronary ostial and nonostial left anterior descending coronary-artery lesions - results from a randomized multicenter trial Journal of the American College of Cardiology 1995 25:1380-1386 DOI:10.1016/0735-1097(95)00008-r PMID:7722137
- Holmes, D. R., Califf, R. M., Topol, E. J. Lessons we have learned from the gusto trial Journal of the American College of Cardiology 1995 25:S10-S17 DOI:10.1016/0735-1097(95)90011-x
- Simes, R. J., Topol, E. J., Holmes, D. R., White, H. D., Rutsch, W. R., Vahanian, A., Simoons, M. L., Morris, D., Betriu, A., Califf, R. M., Ross, A. M. Link between the angiographic substudy and mortality outcomes in a large randomized trial of myocardial reperfusion - importance of early and complete infarct artery reperfusion Circulation 1995 91:1923-1928 PMID:7895348
- Elliott, J. M., Berdan, L. G., Holmes, D. R., Isner, J. M., King, S. B., Keeler, G. P., Kearney, M., Califf, R. M., Topol, E. J. One-year follow-up in the coronary angioplasty versus excisional atherectomy trial (caveat-i) Circulation 1995 91:2158-2166 PMID:7697844
- Lefkovits, J., Holmes, D. R., Califf, R. M., Safian, R. D., Pieper, K., Keeler, G., Topol, E. J. Predictors and sequelae of distal embolization during saphenous-vein graft intervention from the caveat-ii trial Circulation 1995 92:734-740 PMID:7641351
- Nissen, S. E., Pepine, C. J., Bashore, T. M., Block, P. C., Bonchek, L. I., Brinker, J. A., Carabello, B., Douglas, J. S., Elion, J. L., Hirshfeld, J. W., Holmes, D. R., Johnson, W. L., et al. Cardiac angiography without cine film - erecting a tower-of-babel in the cardiac-catheterization laboratory Journal of the American College of Cardiology 1994 24:834-837 PMID:8077561
- Holmes, D. R., Topol, E. J. Dilate or debulk Cleveland Clinic Journal of Medicine 1994 61:124-126 PMID:8194176
- Sutton, J. M., Ellis, S. G., Roubin, G. S., Pinkerton, C. A., King, S. B., Raizner, A. E., Holmes, D. R., Kereiakes, D. J., Topol, E. J. Major clinical events after coronary stenting - the multicenter registry of acute and elective gianturco-roubin stent placement Circulation 1994 89:1126-1137 PMID:8124799
- Kleiman, N. S., White, H. D., Ohman, E. M., Ross, A. M., Woodlief, L. H., Califf, R. M., Holmes, D. R., Bates, E., Pfisterer, M., Vahanian, A., Topol, E. J. Mortality within 24 hours of thrombolysis for myocardial-infarction - the importance of early reperfusion Circulation 1994 90:2658-2665 PMID:7994805
- Holmes, D. R., Topol, E. J., Adelman, A. G., Cohen, E. A., Califf, R. M. Randomized trials of directional coronary atherectomy - implications for clinical-practice and future investigation Journal of the American College of Cardiology 1994 24:431-439 PMID:8034880
- Topol, E. J., Leya, F., Pinkerton, C. A., Whitlow, P. L., Hofling, B., Simonton, C. A., Masden, R. R., Serruys, P. W., Leon, M. B., Williams, D. O., King, S. B., Mark, D. B., et al. A comparison of directional atherectomy with coronary angioplasty in patients with coronary-artery disease New England Journal of Medicine 1993 329:221-227 DOI:10.1056/nejm199307223290401 PMID:8316266
- George, B. S., Voorhees, W. D., Roubin, G. S., Fearnot, N. E., Pinkerton, C. A., Raizner, A. E., King, S. B., Holmes, D. R., Topol, E. J., Kereiakes, D. J., Hartzler, G. O. Multicenter investigation of coronary stenting to treat acute or threatened closure after percutaneous transluminal coronary angioplasty - clinical and angiographic outcomes Journal of the American College of Cardiology 1993 22:135-143 PMID:8509533
- Popma, J. J., Decesare, N. B., Pinkerton, C. A., Kereiakes, D. J., Whitlow, P., King, S. B., Topol, E. J., Holmes, D. R., Leon, M. B., Ellis, S. G. Quantitative-analysis of factors influencing late lumen loss and restenosis after directional coronary atherectomy American Journal of Cardiology 1993 71:552-557 DOI:10.1016/0002-9149(93)90510-j PMID:8438740
- Popma, J. J., Topol, E. J., Hinohara, T., Pinkerton, C. A., Baim, D. S., King, S. B., Holmes, D. R., Whitlow, P. L., Kereiakes, D. J., Hartzler, G. O., Kent, K. M., Ellis, S. G., et al. Abrupt vessel closure after directional coronary atherectomy Journal of the American College of Cardiology 1992 19:1372-1379 PMID:1593028
- Decesare, N. B., Popma, J. J., Holmes, D. R., Dick, R. J., Whitlow, P. L., King, S. B., Pinkerton, C. A., Kereiakes, D. J., Topol, E. J., Haudenschild, C. C., Ellis, S. G. Clinical angiographic and histologic correlates of ectasia after directional coronary atherectomy American Journal of Cardiology 1992 69:314-319 DOI:10.1016/0002-9149(92)90226-o PMID:1734641
- Schwartz, R. S., Holmes, D. R., Topol, E. J. The restenosis paradigm revisited - an alternative proposal for cellular mechanisms Journal of the American College of Cardiology 1992 20:1284-1293 PMID:1401633
- Popma, J. J., Decesare, N. B., Ellis, S. G., Holmes, D. R., Pinkerton, C. A., Whitlow, P., King, S. B., Ghazzal, Z. M. B., Topol, E. J., Garratt, K. N., Kereiakes, D. J. Clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy Journal of the American College of Cardiology 1991 18:1183-1189 PMID:1918694
- Topol, E. J., Holmes, D. R., Rogers, W. J. Coronary angiography after thrombolytic therapy for acute myocardial-infarction Annals of Internal Medicine 1991 114:877-885 PMID:2014950
- Ellis, S. G., Decesare, N. B., Pinkerton, C. A., Whitlow, P., King, S. B., Ghazzal, Z. M. B., Kereiakes, D. J., Popma, J. J., Menke, K. K., Topol, E. J., Holmes, D. R. Relation of stenosis morphology and clinical presentation to the procedural results of directional coronary atherectomy Circulation 1991 84:644-653 PMID:1860208
- Holmes, D. R., Topol, E. J. Reperfusion momentum - lessons from the randomized trials of immediate coronary angioplasty for myocardial-infarction Journal of the American College of Cardiology 1989 14:1572-1578 DOI:10.1016/0735-1097(89)90401-4 PMID:2809019