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Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries

Academic Article
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Overview

related to degree

  • Rosenblum, Jonathan, Ph.D. in Chemistry, Scripps Research 1991 - 1996

authors

  • Barbas III, Carlos
  • Rosenblum, Jonathan
  • Lerner, Richard

publication date

  • July 1993

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • An iterative strategy for the selection of catalytic metalloantibodies is described. The first stage of this strategy is validated by the selection of semisynthetic antibodies that coordinate a variety of different metal ions and the metal oxide magnetite. These results have implications not only for the development of catalytic metalloantibodies but also for the development of reagents for magnetic resonance imaging, delivery of radioisotopes, and purification of recombinant proteins.

subject areas

  • Amino Acid Sequence
  • Antibodies, Catalytic
  • Antibody Specificity
  • Base Sequence
  • Copper
  • Ferrosoferric Oxide
  • Gene Library
  • Genes, Immunoglobulin
  • Humans
  • Immunoglobulin Fab Fragments
  • Iron
  • Metals
  • Models, Molecular
  • Molecular Sequence Data
  • Oxides
  • Selection, Genetic
  • Sequence Analysis
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Research

keywords

  • CATALYTIC ANTIBODIES
  • MAGNETITE
  • METALLOPROTEINS
  • SURFACE EXPRESSION
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Identity

PubMed Central ID

  • PMC46936

International Standard Serial Number (ISSN)

  • 0027-8424

PubMed ID

  • 8341642
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Additional Document Info

start page

  • 6385

end page

  • 6389

volume

  • 90

issue

  • 14

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