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Total synthesis of quinoxapeptin A-C: Establishment of absolute stereochemistry

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Overview

authors

  • Boger, Dale
  • Ledeboer, M. W.
  • Kume, M.
  • Jin, Q.

publication date

  • 1999

journal

  • Angewandte Chemie-International Edition  Journal

abstract

  • The relative and absolute stereochemistry of the naturally occurring potent HIV reverse transcriptase (RT) inhibitors 1 and 2, quinoxapeptin A and B, were established by total synthesis. Their synthetic precursor 3 (dubbed quinoxapeptin C) was found to be a more potent HIV-1 RT inhibitor and to lack the potent cytotoxic activity characteristic of 1 and 2.
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Identity

International Standard Serial Number (ISSN)

  • 1433-7851

Digital Object Identifier (DOI)

  • 10.1002/(sici)1521-3773(19990816)38:16<2424::aid-anie2424>3.0.co;2-9

PubMed ID

  • 10458810
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Additional Document Info

start page

  • 2424

end page

  • 2426

volume

  • 38

issue

  • 16

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