Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Multiple adenovirus serotypes use alpha-v integrins for infection

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Mathias, P.
  • Wickham, T.
  • Moore, M.
  • Nemerow, Glen

publication date

  • October 1994

journal

  • Journal of Virology  Journal

abstract

  • The nucleotide sequence encoding the penton base integrin-binding domains of several human adenoviruses was obtained by homology PCR. Each of the penton base proteins contains a conserved Arg-Gly-Asp (RGD) sequence that is predicted to lie at the apex of two extended alpha helices. The penton base RGD domain promotes efficient infection of host cells by multiple adenovirus serotypes via interaction with alpha v integrins, thus indicating that alpha v integrins play a central role in the entry of adenoviruses into host cells.

subject areas

  • Adenoviruses, Human
  • Amino Acid Sequence
  • Base Sequence
  • Binding Sites
  • Capsid
  • Capsid Proteins
  • Cell Line
  • DNA Primers
  • Humans
  • Integrins
  • Models, Structural
  • Molecular Sequence Data
  • Oligopeptides
  • Polymerase Chain Reaction
  • Protein Structure, Secondary
  • Sequence Homology, Amino Acid
scroll to property group menus

Identity

PubMed Central ID

  • PMC237109

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 8084019
scroll to property group menus

Additional Document Info

start page

  • 6811

end page

  • 6814

volume

  • 68

issue

  • 10

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support