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Evidence for dynorphin-a as a neurotransmitter in rat hippocampus

Academic Article
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Overview

authors

  • Chavkin, C.
  • Bakhit, C.
  • Bloom, Floyd

publication date

  • 1983

journal

  • Life Sciences  Journal

abstract

  • The molecular forms of Dynorphin A immunoreactivity (Dyn A-IR) detected in hippocampus were resolved by reverse-phase high pressure liquid chromatography (C18-HPLC). Peptide co-eluting with synthetic Dyn A(1-17) represents 20% of the total Dyn A-IR. Dyn A-IR was released from hippocampal slices in vitro by a Ca++-dependent mechanism stimulated by superfusion with K+, kainate or veratrine. Released peptides were resolved by C18-HPLC and shown to contain Dyn A-IR co-eluting with synthetic Dyn A(1-17). These observations are consistent with the hypothesis that Dyn A(1-17) acts as a neurotransmitter at synapses in hippocampus.

subject areas

  • Animals
  • Calcium
  • Chromatography, High Pressure Liquid
  • Dynorphins
  • Endorphins
  • Hippocampus
  • Kainic Acid
  • Male
  • Neurotransmitter Agents
  • Peptide Fragments
  • Rats
  • Rats, Inbred Strains
  • Veratrine
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Identity

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(83)90432-0

PubMed ID

  • 6141483
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Additional Document Info

start page

  • 13

end page

  • 16

volume

  • 33

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